Rilzabrutinib for the Adult Participants With Chronic ITP Who Have Completed Phase 3 Study in Japan

NCT ID: NCT07216079

Last Updated: 2025-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-15

Study Completion Date

2026-11-30

Brief Summary

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This is an open-label, multi-center, single group, Phase 3 study for treatment with rilzabrutinib.

The purpose of this study is to provide continuation of rilzabrutinib treatment to adult participants with ITP who have completed the LTE of the LUNA 3 study in Japan, demonstrating clinically meaningful benefit as judged by the Investigator.

Detailed Description

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Conditions

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Immune Thrombocytopenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Rilzabrutinib

400 mg

Group Type EXPERIMENTAL

rilzabrutinib

Intervention Type DRUG

Pharmaceutical form:Tablet-Route of administration:Oral

Interventions

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rilzabrutinib

Pharmaceutical form:Tablet-Route of administration:Oral

Intervention Type DRUG

Other Intervention Names

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SAR444671

Eligibility Criteria

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Inclusion Criteria

* Participants who have been enrolled in and have completed the LTE of the LUNA 3 study with demonstration of efficacy without major safety concern while on study considered by the Investigator to be clinically meaningful.
* Participants who have ongoing diagnosis of primary ITP and continue to require treatment for ITP according to the Investigator.
* Participants who have acceptable benefit/risk profile.
* Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.

Exclusion Criteria

* Participants with secondary ITP.
* Pregnant or lactating women.
* Electrocardiogram (ECG) findings for participants. The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanofi

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Investigational Site Number: 1001

Tsuchiura, Ibaraki, Japan

Site Status

Investigational Site Number: 1002

Kanazawa, Ishikawa-ken, Japan

Site Status

Investigational Site Number: 1003

Iruma-gun, Saitama, Japan

Site Status

Countries

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Japan

Related Links

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Other Identifiers

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U1111-1319-5468

Identifier Type: REGISTRY

Identifier Source: secondary_id

LTS19407

Identifier Type: -

Identifier Source: org_study_id