Molecular Research on Predictive Efficacy and New Therapeutic Targets for Nasopharyngeal Carcinoma

NCT ID: NCT07198802

Last Updated: 2025-09-30

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 600 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-10-31
• Study Completion Date: 2028-12-31

Brief Summary

To analyze the spatiotemporal dynamic evolution of nasopharyngeal carcinoma before and after immunotherapy and during tumor progression, 2~3 key cell subsets or node molecules were screened to predict the curative effect. Spatial metabolome and organoids were used to elucidate the mechanism of key factors leading to immunotherapy tolerance in NPC and identify new targets for intervention.

Conditions

Nasopharyngeal Carcinoma (NPC)

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Study Groups

No Intervention

Intervention Type: OTHER

This project involves no therapeutic intervention for the subjects.

Interventions

No Intervention

This project involves no therapeutic intervention for the subjects.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Clearly diagnosed with nasopharyngeal carcinoma by pathology;

2. Patients who have received combined radiotherapy, chemotherapy and immunotherapy in our hospital;

3. Patients diagnosed in our hospital from January 2025 to December 2028;

4. Have relatively complete clinical data;

5. Age between 15 and 75 years old;

Exclusion Criteria

1. The final diagnosis of the participants is other diseases, including lymphoma, or oropharyngeal cancer, etc.;

2. The participants failed to obtain pathological and imaging data for various reasons;

3. Due to physical conditions, they did not undergo relevant examinations, refused to accept examinations, or interrupted treatment for other reasons, and were unable to complete clinical assessment.

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

WuhanUH 1149-01

Identifier Type: -

Identifier Source: org_study_id