Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation

NCT ID: NCT07198126

Last Updated: 2025-09-30

Basic Information

• Recruitment Status: ENROLLING_BY_INVITATION
• Clinical Phase: NA
• Total Enrollment: 130 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-08-30
• Study Completion Date: 2026-02-28

Brief Summary

Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments.

The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities.

This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism.

The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality.

This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.

Conditions

Pterygium; Corneal Astigmatism

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Group Pterygium Excision with Conjunctival Autograft

Patients will undergo surgical excision of pterygium followed by conjunctival autograft transplantation. The autograft will be harvested from the superior bulbar conjunctiva and secured at the excision site using sutures.

Group Type: EXPERIMENTAL

Pterygium Excision with Conjunctival Autograft

Intervention Type: PROCEDURE

Excision of primary Grade II or Grade III pterygium Conjunctival autograft harvested and transplanted at the excision site Graft secured with sutures

Interventions

Pterygium Excision with Conjunctival Autograft

Excision of primary Grade II or Grade III pterygium Conjunctival autograft harvested and transplanted at the excision site Graft secured with sutures

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Adults of either sex aged >30 to 70 years.
• Phakic eyes.
• Primary pterygium, Grade II or Grade III (as per protocol grading).
• Presence of corneal astigmatism on pre-operative assessment.
• Scheduled for pterygium excision with conjunctival autograft transplantation at the study site.
• Able to provide written informed consent and to attend the 1-month postoperative assessment.

Exclusion Criteria

• Pseudophakic or aphakic eyes.
• Recurrent pterygium.
• Prior keratoplasty or trabeculectomy in the study eye.
• Keratoconus or other corneal pathologies that can independently induce astigmatism.
• Lenticular astigmatism or significant lens pathology affecting refraction.
• Eyes planned for simple pterygium excision without conjunctival autograft.
• Any ocular condition or systemic illness judged likely to interfere with keratometric or refractive measurements, follow-up, or surgical safety.

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mughal Eye Trust Hospital

OTHER

Sponsor Role: lead

Responsible Party

Ayeza Nadeem Butt

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Mughal Eye Hospital Trust

Lahore, Punjab Province, Pakistan

Countries

Pakistan

Other Identifiers

MughalETH1

Identifier Type: -

Identifier Source: org_study_id