Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2030-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is:

• Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients?

Participants:

Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

NCT05692635

Brain Metastases Nonsmall Cell Lung Cancer Stage III

RECRUITING PHASE2

Magnetic Resonance (MR) Imaging & Blood Biomarkers for Head and Neck Cancer

NCT03491176

Cutaneous Squamous Cell Carcinoma of the Head and Neck Healthy Subject Head and Neck Cancer

ACTIVE_NOT_RECRUITING

Application of MRI Radiomics Features in Neoadjuvant Therapy of Head and Neck Squamous Cell Carcinoma

NCT06755567

Head and Neck Cancer Neoadjuvant Therapy Immunotherapy +2 more

NOT_YET_RECRUITING

Magnetic Resonance Imaging-guided Adaptive Radiotherapy for Large Brain Metastases

NCT06405256

Brain Metastases

RECRUITING

MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy

NCT02031237

Brain Metastases

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neuro-Oncology MRI Imaging Tumor Immune Microenvironment

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. conventional MRI revealed intracranial space-occupying lesions and suspected high-grade gliomas, brain metastases and meningiomas；
2. It is planned to perform a brain tumor resection surgery in this institution.

Exclusion Criteria

1. other CNS diseases in addition to brain tumors;
2. pathologically confirmed brain tumors not belonging to any of the three selected types;
3. contraindications to the use of gadolinium contrast, including hypersensitivity to contrast agents, renal dysfunction, pregnancy or lactation;
4. contraindications to MRI;
5. poor image quality unsuitable for subsequent analyses;
6. age younger than 18 years.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No