Study Results
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Basic Information
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COMPLETED
41 participants
OBSERVATIONAL
2024-03-01
2024-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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mild exacerbations
Patients were divided into two groups: mild exacerbations (group 1) and moderate and severe exacerbations (group 2) based on ROME criteria.
Impulse Oscillometry
Impulse Oscillometry (IOS) is a simple, non-invasive, effort-independent method that uses sound waves to detect airway changes quickly. It only requires the patient to breathe normally to assess lung function by measuring both resistance and reactance of the airways. 6,7 These features of IOS suggest it may be a useful test for assessing patient respiratory function during exacerbation periods when airway resistance, airflow limitation, and respiratory muscle weakness further impair breathing.
moderate and severe exacerbations
Patients were divided into two groups: mild exacerbations (group 1) and moderate and severe exacerbations (group 2) based on ROME criteria.
Impulse Oscillometry
Impulse Oscillometry (IOS) is a simple, non-invasive, effort-independent method that uses sound waves to detect airway changes quickly. It only requires the patient to breathe normally to assess lung function by measuring both resistance and reactance of the airways. 6,7 These features of IOS suggest it may be a useful test for assessing patient respiratory function during exacerbation periods when airway resistance, airflow limitation, and respiratory muscle weakness further impair breathing.
Interventions
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Impulse Oscillometry
Impulse Oscillometry (IOS) is a simple, non-invasive, effort-independent method that uses sound waves to detect airway changes quickly. It only requires the patient to breathe normally to assess lung function by measuring both resistance and reactance of the airways. 6,7 These features of IOS suggest it may be a useful test for assessing patient respiratory function during exacerbation periods when airway resistance, airflow limitation, and respiratory muscle weakness further impair breathing.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients who were unable to perform spirometry during exacerbation or had a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio of ≥ 0.70 were also excluded.
ALL
No
Sponsors
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Deniz Bilici
OTHER
Responsible Party
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Deniz Bilici
md
Principal Investigators
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Esma Seda Akalın, MD
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medeniyet University
Deniz Koçak, Research Assistant
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medeniyet University
Elif Hazal Karadağ, Research Assistant
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medeniyet University
Burcu Arpınar Yiğitbaş, Associate professor:
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medeniyet University
Deniz Bilici, MD
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medeniyet University
Handan Ankaralı, Professor
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medeniyet University
Locations
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Istanbul Medeniyet University
Istanbul, , Turkey (Türkiye)
Countries
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References
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Huang Y, Zhang X, Wang J, Bao W, Lv C, Zhang Y, Tian X, Zhou Y, Zhang M. Role of impulse oscillometry in chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap. Clin Transl Allergy. 2025 Apr;15(4):e70057. doi: 10.1002/clt2.70057.
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Zheng S, Hu Y, Chen Z, Wang M, Liao W. Predicting asthma exacerbation by impulse oscillometry evaluation of small airway function and fractional exhaled nitric oxide in preschool children. Pediatr Pulmonol. 2020 Jul;55(7):1601-1607. doi: 10.1002/ppul.24790. Epub 2020 Apr 30.
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Ling Y, Si M, Niu Y, Han Y, Xu Y. The predictive value of impulse oscillometry for asthma exacerbations in childhood: A systematic review and meta-analyses. Pediatr Pulmonol. 2021 Jul;56(7):1850-1856. doi: 10.1002/ppul.25374. Epub 2021 Mar 23.
Park H, Lee HJ, Lee HW, Park TY, Heo EY, Kim DK, Lee JK. Diagnosis and evaluation of small airway disease and COPD using impulse oscillometry. Sci Rep. 2024 Nov 14;14(1):28030. doi: 10.1038/s41598-024-79818-w.
Su ZQ, Guan WJ, Li SY, Ding M, Chen Y, Jiang M, Chen XB, Zhong CH, Tang CL, Zhong NS. Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD. Int J Chron Obstruct Pulmon Dis. 2018 Oct 1;13:3031-3044. doi: 10.2147/COPD.S172639. eCollection 2018.
Duman D, Tasti OF, Merve Tepetam F. Assessment of small airway dysfunction by impulse oscillometry (IOS) in COPD and IPF patients. Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):3033-3044. doi: 10.26355/eurrev_202304_31937.
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Lipworth BJ, Jabbal S. What can we learn about COPD from impulse oscillometry? Respir Med. 2018 Jun;139:106-109. doi: 10.1016/j.rmed.2018.05.004. Epub 2018 May 16.
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Komarow HD, Myles IA, Uzzaman A, Metcalfe DD. Impulse oscillometry in the evaluation of diseases of the airways in children. Ann Allergy Asthma Immunol. 2011 Mar;106(3):191-9. doi: 10.1016/j.anai.2010.11.011. Epub 2011 Jan 6.
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1.Agustí A, Celli BR, Criner GJ et al. Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Eur Respir J 2023; 61(4):2300239. 2.Wedzicha JA, Seemungal TA. COPD exacerbations: defining their cause and prevention. Lancet 2007; 370(9589): 786-796.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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20.12.2023; 2023/0971
Identifier Type: -
Identifier Source: org_study_id
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