Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty
NCT ID: NCT07180953
Last Updated: 2025-09-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
90 participants
INTERVENTIONAL
2025-09-01
2025-10-30
Brief Summary
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The goal of this clinical trial is to learn how the route of dexamethasone administration (either through the vein or nerve block) affects pain and inflammation in people having total knee replacement surgery. All participants will receive two types of nerve blocks before surgery: an iPACK block and an adductor canal block (ACB), which help control pain after the operation.
The main questions the study aims to answer are:
Does injecting dexamethasone into the nerve block reduce pain more effectively than giving it by vein? Which method leads to a lower inflammatory response after surgery? Researchers will compare the two groups to see which route offers better pain relief and less swelling after knee surgery.
Participants will:
Be randomly assigned to receive dexamethasone either in the nerve block or by IV Receive standard care for total knee replacement Rate their pain and have blood tests after surgery to measure inflammation
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Control
iPACK block with ACB
NaCl 0.9%
iPACK block with Adductor Canal Block (2 x 20ml 0.2% ropivacaine + 1ml 0.9% NaCl) + 2ml 0.9% NaCl iv
iv DEX
iPACK block with ACB + iv Dexamethasone
Dexamethasone 4mg
iPACK block with Adductor Canal Block (2 x 20ml 0.2% ropivacaine + 1ml 0.9% NaCl) + 4mg Dexamethasone iv
pn DEX
iPACK block with ACB + perineural Dexamethasone
Dexamethasone 4mg
iPACK block with Adductor Canal Block (2 x 20ml 0.2% ropivacaine + 2mg Dexamethasone) + 2ml 0.9% NaCl iv
Interventions
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NaCl 0.9%
iPACK block with Adductor Canal Block (2 x 20ml 0.2% ropivacaine + 1ml 0.9% NaCl) + 2ml 0.9% NaCl iv
Dexamethasone 4mg
iPACK block with Adductor Canal Block (2 x 20ml 0.2% ropivacaine + 1ml 0.9% NaCl) + 4mg Dexamethasone iv
Dexamethasone 4mg
iPACK block with Adductor Canal Block (2 x 20ml 0.2% ropivacaine + 2mg Dexamethasone) + 2ml 0.9% NaCl iv
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* patients aged \>65 and \<100 years
* patients can provide informed consent
* patients can reliably report symptoms to the research team
Exclusion Criteria
* language barrier
* infection at the site of the regional block,
* coagulation disorders,
* immunodeficiency,
* American Society of Anesthesiologists (ASA) physical status of IV or higher,
* history of regular steroid medication.
65 Years
100 Years
ALL
No
Sponsors
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Poznan University of Medical Sciences
OTHER
Responsible Party
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Locations
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Poznan University of Medical Sciences
Poznan, , Poland
Countries
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Central Contacts
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Grzegorz Kowalski, MD PhD
Role: CONTACT
Facility Contacts
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Other Identifiers
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02/20025
Identifier Type: -
Identifier Source: org_study_id
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