Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty
NCT ID: NCT02102815
Last Updated: 2019-01-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
100 participants
INTERVENTIONAL
2014-05-31
2016-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Dexamethasone
Preoperative dexamethasone 0.15mg/Kg mixed with NSS to 50 mL IV slowly push over 5 minutes
Dexamethasone
Dexamethasone 0.15mg/kg mixed with NSS up to 50 mL IV slowly push over 5 minutes
Placebo
Preoperative intravenous normal saline 50 mL slowly push over 5 minutes
Normal saline
NSS 50 mL IV slowly push over 5 minutes
Interventions
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Dexamethasone
Dexamethasone 0.15mg/kg mixed with NSS up to 50 mL IV slowly push over 5 minutes
Normal saline
NSS 50 mL IV slowly push over 5 minutes
Eligibility Criteria
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Inclusion Criteria
* 50-85 years old
* ASA class 1-3
Exclusion Criteria
* History of drug allergies: steroids
* Renal impairment (CrCl \<30 mL/min)
* Liver impairment
* Cognitive function disorders
* Poor controlled DM (HA1C \> 7.5)
* Morning DTX at operative day \> 180 mg%
* Received corticosteroids within 3 months before surgery
50 Years
85 Years
ALL
No
Sponsors
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Thammasat University
OTHER
Responsible Party
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Supakit Kanitnate
Orthopaedics department
Principal Investigators
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Supakit Kanitnate, M.D.
Role: PRINCIPAL_INVESTIGATOR
Orthopaedics department, Thammasat University
Locations
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Orthopaedic department, Faculty of medicine, Thammasat university
Klongluang, Changwat Pathum Thani, Thailand
Countries
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Other Identifiers
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OrthoTU06
Identifier Type: -
Identifier Source: org_study_id
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