Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.

NCT ID: NCT07169656

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

15000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-03

Study Completion Date

2032-12-31

Brief Summary

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This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.

Detailed Description

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Conditions

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Chronic Hepatitis b

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

ETV,TDF,TAF,TMF

Intervention Type DRUG

treated with entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), or tenofovir amibufenamide (TMF)

Group 2

Peginterferon α-2b injection

Intervention Type DRUG

treated with Peginterferon α-2b injection

Interventions

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ETV,TDF,TAF,TMF

treated with entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), or tenofovir amibufenamide (TMF)

Intervention Type DRUG

Peginterferon α-2b injection

treated with Peginterferon α-2b injection

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 1.Chronic HBV infection (HBsAg-positive for ≥6 months); 2.Age ≥18 years; 3.Patients who, based on real-world clinical practice needs, are planned or currently receiving treatment with:Entecavir (ETV),Tenofovir disoproxil fumarate (TDF),Tenofovir alafenamide fumarate (TAF),Tenofovir amibufenamide (TMF) OR Pegylated interferon α-2b-naïve patients OR Patients re-initiating pegylated interferon α-2b therapy; 4.Written informed consent obtained from the patient.

Exclusion Criteria

* 1.Severe hepatic dysfunction or decompensated cirrhosis; 2.Concurrent participation in other clinical trials; 3.Hepatocellular carcinoma (HCC).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The First Affiliated Hospital of Zhengzhou University

OTHER

Sponsor Role lead

Responsible Party

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Hongxia Liang

Chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hongxia Liang

Role: PRINCIPAL_INVESTIGATOR

The First Affiliated Hospital of Zhengzhou University

Locations

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Huaxian People's Hospital

Anyang, , China

Site Status RECRUITING

Linzhou City People's Hospital

Anyang, , China

Site Status RECRUITING

Neihuang County People's Hospital

Anyang, , China

Site Status RECRUITING

Tangyin County People's Hospital

Anyang, , China

Site Status RECRUITING

The Fifth People's Hospital of Anyang

Anyang, , China

Site Status RECRUITING

The First Affiliated Hospital of Xinxiang Medical University (Hua County Branch)

Anyang, , China

Site Status RECRUITING

Guangzhou First People's Hospital

Guangzhou, , China

Site Status RECRUITING

The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital)

Guangzhou, , China

Site Status RECRUITING

Hebi Coal Mining Group General Hospital

Hebi, , China

Site Status RECRUITING

Hebi Infectious Disease Hospital

Hebi, , China

Site Status RECRUITING

Junxian County People's Hospital

Hebi, , China

Site Status RECRUITING

Bo'ai County People's Hospital

Jiaozuo, , China

Site Status RECRUITING

Mengzhou Hospital of Traditional Chinese Medicine

Jiaozuo, , China

Site Status RECRUITING

Qinyang People's Hospital

Jiaozuo, , China

Site Status RECRUITING

The Secend People's Hospital of Jiaozuo

Jiaozuo, , China

Site Status RECRUITING

The Third People's Hospital of Jiaozuo

Jiaozuo, , China

Site Status RECRUITING

Xiuwu People's Hospital

Jiaozuo, , China

Site Status RECRUITING

Wenxian People's Hospital

Jiayuguan, , China

Site Status RECRUITING

Jiyang County Hospital of Traditional Chinese Medicine

Jinan, , China

Site Status RECRUITING

Shandong Public Health Clinical Center

Jinan, , China

Site Status RECRUITING

Jiyuan People's Hospital

Jiyuan, , China

Site Status RECRUITING

Jiyuan Traditional Chinese Medicine Hospital

Jiyuan, , China

Site Status RECRUITING

Huaihe Hospital of Henan University

Kaifeng, , China

Site Status RECRUITING

Infectious Diseases Hospital of Kaifeng

Kaifeng, , China

Site Status RECRUITING

Kaifeng Central Hospital

Kaifeng, , China

Site Status RECRUITING

Kaifeng Hospital of Traditional Chinese Medicine

Kaifeng, , China

Site Status RECRUITING

Lankao First Hospital Group

Kaifeng, , China

Site Status RECRUITING

Qixian People's Hospital

Kaifeng, , China

Site Status RECRUITING

The People's Hospital of Weishi

Kaifeng, , China

Site Status RECRUITING

Tongxu County People's Hospital

Kaifeng, , China

Site Status RECRUITING

Weishi County People's Hospital

Kaifeng, , China

Site Status RECRUITING

Linyi Hospital of Traditional Chinese Medicine

Linyi, , China

Site Status RECRUITING

Linyi People's Hospital

Linyi, , China

Site Status RECRUITING

Linying County People's Hospital

Luohe, , China

Site Status RECRUITING

Luohe Central Hospital

Luohe, , China

Site Status RECRUITING

Luanchuan County People's Hospital

Luoyang, , China

Site Status RECRUITING

Luoning County People's Hospital

Luoyang, , China

Site Status RECRUITING

Luoyang Central Hospital

Luoyang, , China

Site Status RECRUITING

Luoyang First People's Hospital

Luoyang, , China

Site Status RECRUITING

Luoyang Third People's Hospital

Luoyang, , China

Site Status RECRUITING

Ruyang County People's Hospital

Luoyang, , China

Site Status RECRUITING

The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, , China

Site Status RECRUITING

Xin'an County People's Hospital

Luoyang, , China

Site Status RECRUITING

Yichuan County Hospital of Traditional Chinese Medicine

Luoyang, , China

Site Status RECRUITING

Yiyang County People's Hospital

Luoyang, , China

Site Status RECRUITING

Dengzhou Central Hospital

Nanyang, , China

Site Status RECRUITING

Dengzhou People's Hospital

Nanyang, , China

Site Status RECRUITING

Fangcheng County People's Hospital

Nanyang, , China

Site Status RECRUITING

Nanyang Central Hospital

Nanyang, , China

Site Status RECRUITING

Nanyang First People's Hospital

Nanyang, , China

Site Status RECRUITING

Nanyang Oilfield General Hospital

Nanyang, , China

Site Status RECRUITING

Nanyang Second General Hospital

Nanyang, , China

Site Status RECRUITING

Nanzhao County People's Hospital

Nanyang, , China

Site Status RECRUITING

Neixiang County People's Hospital

Nanyang, , China

Site Status RECRUITING

Sheqi County People's Hospital

Nanyang, , China

Site Status RECRUITING

Tanghe County People's Hospital

Nanyang, , China

Site Status RECRUITING

The First Affiliated Hospital of Nanyang Medical College

Nanyang, , China

Site Status RECRUITING

Xinye County People's Hospital

Nanyang, , China

Site Status RECRUITING

Xixia County People's Hospital

Nanyang, , China

Site Status RECRUITING

Zhenping People's Hospital

Nanyang, , China

Site Status RECRUITING

Ningbo Medical Center Iihuili hospital

Ningbo, , China

Site Status RECRUITING

General Hospital Of Pingmei Shenma Group

Pingdingshan, , China

Site Status RECRUITING

Lushan County People's Hospital

Pingdingshan, , China

Site Status RECRUITING

People's Hospital of Baofeng

Pingdingshan, , China

Site Status RECRUITING

Pingdingshan First People's Hospital

Pingdingshan, , China

Site Status RECRUITING

Ruzhou First People's Hospital

Pingdingshan, , China

Site Status RECRUITING

Ye County People's Hospital

Pingdingshan, , China

Site Status RECRUITING

Pingdu Municipal People's Hospital

Pingdu, , China

Site Status RECRUITING

Anyang District Hospital

Pujiang, , China

Site Status RECRUITING

Chinese Medicine Hospital of puyang

Pujiang, , China

Site Status RECRUITING

Fanxian People's Hospital

Pujiang, , China

Site Status RECRUITING

Nanle County People's Hospital

Pujiang, , China

Site Status RECRUITING

Puyang People's Hospital

Pujiang, , China

Site Status RECRUITING

The Fifth People's Hospital of Puyang City

Pujiang, , China

Site Status RECRUITING

People's Hospital of Rizhao

Rizhao, , China

Site Status RECRUITING

Huanghe Sanmenxia Hospital

Sanmenxia, , China

Site Status RECRUITING

Sanmenxia Central Hospital

Sanmenxia, , China

Site Status RECRUITING

The First People's Hospital of Lingbao

Sanmenxia, , China

Site Status RECRUITING

The Sixth People's Hospital of Lingbao

Sanmenxia, , China

Site Status RECRUITING

Yimei Group General Hospital

Sanmenxia, , China

Site Status RECRUITING

Minquan County Hospital of Traditional Chinese Medicine

Shangqiu, , China

Site Status RECRUITING

Minquan County People's Hospital

Shangqiu, , China

Site Status RECRUITING

Second People's Hospital Xiayi Country

Shangqiu, , China

Site Status RECRUITING

Shangqiu Fourth People's Hospital

Shangqiu, , China

Site Status RECRUITING

Shangqiu Hospital of Traditional Chinese Medicine

Shangqiu, , China

Site Status RECRUITING

Shangqiu Municipal Hospital

Shangqiu, , China

Site Status RECRUITING

Shangqiu Third People's Hospital

Shangqiu, , China

Site Status RECRUITING

Sui County People's Hospital

Shangqiu, , China

Site Status RECRUITING

Suixian County Hospital of Traditional Chinese Medicine

Shangqiu, , China

Site Status RECRUITING

The First People's Hospital of Shangqiu

Shangqiu, , China

Site Status RECRUITING

The People's Hospital of Yucheng County

Shangqiu, , China

Site Status RECRUITING

Xiayi County People's Hospital

Shangqiu, , China

Site Status RECRUITING

Yongcheng Central Hospital

Shangqiu, , China

Site Status RECRUITING

Yucheng County People's Hospital

Shangqiu, , China

Site Status RECRUITING

Zhecheng People's Hospital

Shangqiu, , China

Site Status RECRUITING

Zhecheng Traditional Chinese Medicine Hospital Co., Ltd.

Shangqiu, , China

Site Status RECRUITING

Changyuan County People's Hospital

Xinxiang, , China

Site Status RECRUITING

Huixian People's Hospital

Xinxiang, , China

Site Status RECRUITING

The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, , China

Site Status RECRUITING

The Third Affiliated Hospital of Xinxiang Medical University

Xinxiang, , China

Site Status RECRUITING

Xinxiang First People's Hospital

Xinxiang, , China

Site Status RECRUITING

Xinxiang Infectious Disease Hospital

Xinxiang, , China

Site Status RECRUITING

Yanjin County People's Hospital

Xinxiang, , China

Site Status RECRUITING

Guangshan County People's Hospital

Xinyang, , China

Site Status RECRUITING

Gushi County People's Hospital

Xinyang, , China

Site Status RECRUITING

Huaibin County People's Hospital

Xinyang, , China

Site Status RECRUITING

Huangchuan County People's Hospital

Xinyang, , China

Site Status RECRUITING

Luoshan County People's Hospital

Xinyang, , China

Site Status RECRUITING

Xinyang Central Hospital

Xinyang, , China

Site Status RECRUITING

Xinyang Specialized Hospital for Infectious Diseases

Xinyang, , China

Site Status RECRUITING

Xixian People's Hospital

Xinyang, , China

Site Status RECRUITING

Changge People's Hospital

Xuchang, , China

Site Status RECRUITING

Xiangcheng County Traditional Chinese Medicine Hospital

Xuchang, , China

Site Status RECRUITING

Xiangcheng People's Hospital

Xuchang, , China

Site Status RECRUITING

Xuchang Central Hospital

Xuchang, , China

Site Status RECRUITING

Xuchang People's Hospital

Xuchang, , China

Site Status RECRUITING

Yanling County People's Hospital

Xuchang, , China

Site Status RECRUITING

Yanling County Traditional Chinese Medicine Hospital

Xuchang, , China

Site Status RECRUITING

Yuzhou Central Hospital

Xuchang, , China

Site Status RECRUITING

Yuzhou City People's Hospital

Xuchang, , China

Site Status RECRUITING

Chinese People's Liberation Army Joint Logistics Support Force 970 Hospital,

Yantai, , China

Site Status RECRUITING

Jiaozuo People's Hospital

Yantai, , China

Site Status RECRUITING

Yantai Qishan Hospital

Yantai, , China

Site Status RECRUITING

Gongyi City People's Hospital

Zhengzhou, , China

Site Status RECRUITING

The First Affiliated Hospital of Henan University of Chinese Medicine

Zhengzhou, , China

Site Status RECRUITING

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, , China

Site Status RECRUITING

The First People's Hospit of Zhengzhou

Zhengzhou, , China

Site Status RECRUITING

The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, , China

Site Status RECRUITING

The Six People's Hospit of Zhengzhou

Zhengzhou, , China

Site Status RECRUITING

The Third People's Hospit of Zhengzhou

Zhengzhou, , China

Site Status RECRUITING

Third Affiliated Hospital of Henan University of Traditional Chinese Medicine

Zhengzhou, , China

Site Status RECRUITING

Xingyang People's Hospital

Zhengzhou, , China

Site Status RECRUITING

Zhengzhou Central Hospital

Zhengzhou, , China

Site Status RECRUITING

Zhengzhou Traditional Chinese Medicine Hospital

Zhengzhou, , China

Site Status RECRUITING

Zhongmu County Hospital of Traditional Chinese Medicine

Zhengzhou, , China

Site Status RECRUITING

Zhongmu County People's Hospital

Zhengzhou, , China

Site Status RECRUITING

Zhongshan Second People's Hospital

Zhongshan, , China

Site Status RECRUITING

Dancheng County People's Hospital

Zhoukou, , China

Site Status RECRUITING

Fugou County People's Hospital

Zhoukou, , China

Site Status RECRUITING

Shenqiu People's Hospital

Zhoukou, , China

Site Status RECRUITING

Taikang County People's Hospital

Zhoukou, , China

Site Status RECRUITING

The Frist People's Hospital Of Xiangcheng

Zhoukou, , China

Site Status RECRUITING

The People's Hospital Of Luyi

Zhoukou, , China

Site Status RECRUITING

Xihua County Hospital of Traditional Chinese Medicine

Zhoukou, , China

Site Status RECRUITING

Xihua County People's Hospital

Zhoukou, , China

Site Status RECRUITING

Zhoukou Central Hospital

Zhoukou, , China

Site Status RECRUITING

Zhoukou Hospital Of TCM

Zhoukou, , China

Site Status RECRUITING

Zhoukou Specialized Disease Hospital

Zhoukou, , China

Site Status RECRUITING

People's Hospital of Queshan

Zhumadian, , China

Site Status RECRUITING

Pingyu County People's Hospital

Zhumadian, , China

Site Status RECRUITING

Runan County Hospital of Traditional Chinese Medicine

Zhumadian, , China

Site Status RECRUITING

Shangcai County People's Hospital

Zhumadian, , China

Site Status RECRUITING

The 990th Hospital of the Joint Logistics Support Force of the PLA

Zhumadian, , China

Site Status RECRUITING

The People's Hospital Of Biyang Country

Zhumadian, , China

Site Status RECRUITING

Xincai County People's Hospital

Zhumadian, , China

Site Status RECRUITING

Xincai Medical University

Zhumadian, , China

Site Status RECRUITING

Xiping County People's Hospital

Zhumadian, , China

Site Status RECRUITING

Zhengyang County People's Hospital

Zhumadian, , China

Site Status RECRUITING

Zhumadian Central Hospital

Zhumadian, , China

Site Status RECRUITING

Zhumadian Traditional Chinese Medicine Hospital

Zhumadian, , China

Site Status RECRUITING

Zibo Central Hospital

Zibo, , China

Site Status RECRUITING

Zibo Infectious Diseases Hospital (Zibo Fourth People's Hospital)

Zibo, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Hongxia Liang

Role: CONTACT

18595871806

Facility Contacts

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Chongwei Hu

Role: primary

Mingye Liu

Role: primary

Jinxiu Li

Role: primary

Fengge Yin

Role: primary

Yuzhong Wang

Role: primary

Hengwei Ji

Role: primary

Qi Zhan

Role: primary

Xujing Liang

Role: primary

Zhanfeng Xie

Role: primary

Weili Niu

Role: primary

Yunli Jia

Role: primary

Daqing Guo

Role: primary

Zengyuan Fu

Role: primary

Donghai Chen

Role: primary

Yuliang Zhao

Role: primary

Zhiqi Han

Role: primary

Chao Zhang

Role: primary

Guoqing Chen

Role: primary

Jian Yao

Role: primary

Xiaoying Li

Role: primary

Chao Liang

Role: primary

Yuye Wu

Role: primary

Zhenkun He

Role: primary

Peng Lei

Role: primary

Yong'an Zhou

Role: primary

Qinghua Zhao

Role: primary

Bing Zhang

Role: primary

Xuelong Liang

Role: primary

Kaiqin Liu

Role: primary

Ying Tang

Role: primary

Hongxia Zhu

Role: primary

Hezheng Shen

Role: primary

Feng Gao

Role: primary

Yadong Xing

Role: primary

Yuli Meng

Role: primary

Guangsong Li

Role: primary

Xiubin Hao

Role: primary

Guoqiang Zhang

Role: primary

Hua Li

Role: primary

Hongbo Ji

Role: primary

Xianwei Shang

Role: primary

Xinjun Hu

Role: primary

Lanfen Bai

Role: primary

Xinshui Ye

Role: primary

Yaohuan Li

Role: primary

Chunge Tian

Role: primary

Xinghong Peng

Role: primary

Dong Wang

Role: primary

Xizeng Zhu

Role: primary

Daimeng Shi

Role: primary

Qiaoli Yu

Role: primary

Xuexiang Wang

Role: primary

Changliang Huang

Role: primary

Xiaobo Li

Role: primary

Qinglin Zhou

Role: primary

Hongxun He

Role: primary

Yu Zhang

Role: primary

Ruichao Li

Role: primary

Yongling Qiao

Role: primary

Liguo Yang

Role: primary

Hua Ye

Role: primary

Guodong Zhang

Role: primary

Yin Liu

Role: primary

Zengyan Yang

Role: primary

Hongde Ma

Role: primary

Dongdong Yang

Role: primary

Lin Zhou

Role: primary

Shuilin Wang

Role: primary

Shuli Jin

Role: primary

Jing Wang

Role: primary

Xianliang Sang

Role: primary

Zhibo Ren

Role: primary

Xiangan Song

Role: primary

Weina Zhang

Role: primary

Tao Ding

Role: primary

Huanhuan Su

Role: primary

Xiaoping Dong

Role: primary

Nana Meng

Role: primary

Wanfeng Wang

Role: primary

Jihong Li

Role: primary

Shifeng Han

Role: primary

Yong Cui

Role: primary

Jingwen Sun

Role: primary

Fajun Jia

Role: primary

Xiaolei Zhu

Role: primary

Shixi Zhang

Role: primary

Kun Lu

Role: primary

Yanling Yang

Role: primary

Hongbo Wang

Role: primary

Yaqing Liu

Role: primary

Shengli Ma

Role: primary

Yu Zhao

Role: primary

Houfeng Zhai

Role: primary

Mintian Wu

Role: primary

Jianguo Wang

Role: primary

Caiying Luo

Role: primary

Wuxue Niu

Role: primary

Fuqiang Li

Role: primary

Daokun Yang

Role: primary

Qian Dou

Role: primary

Yali Yang

Role: primary

Zhengyan Wen

Role: primary

Gaoxian Li

Role: primary

Zhaohai Zeng

Role: primary

Mingren Shi

Role: primary

Jianye Ding

Role: primary

Jianhong Wu

Role: primary

Jianzhi Gu

Role: primary

Haiyan Chen

Role: primary

Honglei Li

Role: primary

Wenhua Zhai

Role: primary

Huage Zhao

Role: primary

Jianhong Yang

Role: primary

Xueqin Yan

Role: primary

Weihong Li

Role: primary

Xia Zhang

Role: primary

Wei Zhang

Role: primary

Yongzhen Tian

Role: primary

Qianqian Chen

Role: primary

Hongmin Si

Role: primary

Yi Zhao

Role: primary

Jikang Yang

Role: primary

Haifeng Yu

Role: primary

Li Yang

Role: primary

Suping Ma

Role: primary

Huijiang Yu

Role: primary

Shujun Wang

Role: primary

Gaofeng Lu

Role: primary

Guangming Li

Role: primary

Dan Zhao

Role: primary

Yansheng Li

Role: primary

Gaoyu Chen

Role: primary

Huili Wu

Role: primary

Hongwei Luo

Role: primary

Guoqiang Liang

Role: primary

Qiaoxia Chen

Role: primary

Qianhua Zhang

Role: primary

Qi Yang

Role: primary

Baoping Xu

Role: primary

Xianyang Li

Role: primary

Xueqiang Liu

Role: primary

Hongwei Wang

Role: primary

Gaoju Li

Role: primary

Rui Yin

Role: primary

Yanfang Zou

Role: primary

Jiaqi Zhang

Role: primary

Jiawei Zhang

Role: primary

Mengshan Jia

Role: primary

Ruinian Zhang

Role: primary

Jingzhen Zhang

Role: primary

Junling Han

Role: primary

Weiping Li

Role: primary

Chun Yuan

Role: primary

Wei Zhang

Role: primary

Shumei Guo

Role: primary

Daliang Yang

Role: primary

Junping Chen

Role: primary

Minghui Yu

Role: primary

Guifu Shi

Role: primary

Yufu Wang

Role: primary

Yanqing Xing

Role: primary

Gang Li

Role: primary

Other Identifiers

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2024-KY-0976-001

Identifier Type: -

Identifier Source: org_study_id

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