A Study of OL-CD19-GDT in Relapsed/ Refractory Autoimmune Diseases

NCT ID: NCT07167537

Last Updated: 2025-09-11

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 44 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-10-31
• Study Completion Date: 2028-12-31

Brief Summary

This study aims to characterize the safety, tolerability, pharmacokinetics, and preliminary efficacy of OL-CD19-GDT in relapsed/refractory autoimmune diseases.

Detailed Description

This is an open-label, single-arm, clinical study to evaluate the efficacy and safety of CAR-T therapy OL-CD19-GDT in the treatment of Relapsed/ Refractory Autoimmune Diseases such as SSc and pSS.

Conditions

Systemic Sclerosis (SSc); Primary Sjogren's Syndrome

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

OL-CD19-GDT

Group Type: EXPERIMENTAL

OL-CD19-GDT

Intervention Type: BIOLOGICAL

OL-CD19-GDT will be given through IV bolus with ascending dose levels to determine the RDE and RP2D as specified in the protocol

Interventions

OL-CD19-GDT

OL-CD19-GDT will be given through IV bolus with ascending dose levels to determine the RDE and RP2D as specified in the protocol

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• Adults aged 18-65 years old
• ECOG 0-2
• Adequate organ function
• Females of childbearing potential (FCBP) must have a negative pregnancy test at screening and must agree to use a highly effective contraceptive method starting from the time of lymphodepletion and for 2 years after dosing of the IMP
• SSc specific:

a)Fulfilling the 2013 ACR/EULAR classification criteria of SSc; b) mRSS score >10; c) at least one vital organ involvement besides the skin; d)relapsed or refractory to at least one immunosuppressant or biologic.

• pSS specfic: a)Fulling the 2016 EULAR/ACR classification critieria for pSS; b) anti-Ro/anti-SSA antibody positive; c) ESSDAI score ≥5 ; d)relapsed or refractory to at least one immunosuppressant or biologic.

Exclusion Criteria

• Active uncontrolled infection
• Serologic evidence of chronic hepatitis B virus (HBV) infection and unable or unwilling to receive standard prophylactic antiviral therapy or with detectable HBV viral load
• Serologic evidence of hepatitis C virus (HCV) infection without completion of curative treatment or with detectable HCV viral load
• HIV antibody positive
• Syphilis antibody positive
• Active tuberculosis, untreated or inadequately treated latent tuberculosis infection (LTBI)
• History of serious infection within 3 months prior to screening (defined as requiring hospitalization or intravenous antimicrobial therapy), or history of oral antimicrobial therapy within 1 month prior to screening (e.g., viral infections, opportunistic infections, including but not limited to severe cytomegalovirus or herpes virus infections)
• Congenital long QT syndrome or a corrected QTcF interval of ≥480 ms at screening (unless secondary to pacemaker or bundle branch block)
• Uncontrolled hypertension (blood pressure ≥160/100 mm Hg repeatedly), unstable angina, congestive heart failure (greater than New York Heart Association class II), electrocardiographic evidence of acute ischemia, coronary angioplasty or myocardial infarction within 6 months prior to screening, uncontrolled atrial or ventricular cardiac arrhythmia, poorly controlled diabetes or other endocrine diseases, severe chronic pulmonary disease, or other serious medical condition which is likely to significantly impair the patient's ability to tolerate the study treatment
• history of organ transplant
• Pregnancy or lactating women
• Use of any other experimental medication within 4 weeks or 5 half-lives prior to start of study drug
• Use of biologics within 10 weeks, stem cell transplant within 6 months prior to the start of study drug
• Prior CAR-T treatment
• Received live or attenuated vaccine within 4 weeks of Cycle 1 Day 1
• Presence of other autoimmune or auto-inflammatory diseases that may affect study assessments, such as rheumatoid arthritis, gout, or active fibromyalgia syndrome.
• Limited to patients diagnosed with SSc: at risk for scleroderma renal crisis; SSc-associated gastric antral vascular ectasia; Severe gastrointestinal involvement leading to malabsorption or intestinal failure
• Limited to patients diagnosed with pSS: primary biliary cholangitis

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Overland Therapeutics

UNKNOWN

Sponsor Role: collaborator

Beijing GoBroad Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jing Pan

Director of the department of Immunotherapy for Hematopoietic Malignancies

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Beijing GoBroad Hospital

Beijing, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Shaocong Miao

Role: CONTACT

miaosc@gobroadhealthcare.com

86+18831006667

Other Identifiers

OL-CD19-GDT-002

Identifier Type: -

Identifier Source: org_study_id