Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice
NCT ID: NCT07164248
Last Updated: 2025-09-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
74 participants
OBSERVATIONAL
2025-06-01
2025-08-01
Brief Summary
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Key objectives are:
Comparing the BMD indications and results requested from the gynecology department with the indications and BMD results requested from other departments. Thus, the BMD scores of patients with hypogonadism can be compared with other groups at risk for bone health.
To assess BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency, functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To analyze the relationship between gynecologic clinical features-such as age at menarche and duration of amenorrhea-and BMD Z-scores.
By combining clinical, hormonal, and densitometric data, this study aims to identify risk factors for low bone density in adolescents, support earlier recognition of osteopenia/osteoporosis, and provide guidance for appropriate interventions in adolescent gynecology practice.
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Detailed Description
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This retrospective study focuses on female adolescents aged 12-21 years who underwent dual-energy X-ray absorptiometry (DEXA) scans at a tertiary care center. The cohort includes patients referred from the adolescent gynecology clinic as well as those referred from other medical departments.
The study objectives are:
To compare referral indications for BMD testing between gynecology and other specialties.
To evaluate differences in BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency (POI), functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To examine the relationship between clinical features (such as age at menarche and duration of amenorrhea) and BMD outcomes within the gynecology group.
The analysis will provide insight into how referral patterns, gynecologic and endocrine conditions, and clinical characteristics influence bone health in adolescent girls. By highlighting risk factors for low BMD, the study aims to support earlier recognition and management of bone health problems in this population.
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Study Groups
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Cohort 1 - Adolescent gynecology referrals
Patients referred for DEXA scans due to gynecologic indications such as hypogonadism, amenorrhea, premature ovarian insufficiency \[POI\], functional hypothalamic amenorrhea \[FHA\], or hypogonadotropic hypogonadism
No interventions assigned to this group
Cohort 2 - Referrals from other specialties
Patients referred for DEXA scans by other departments, such as pediatrics, endocrinology, or additional medical specialties
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Underwent bone mineral density (BMD) measurement with DEXA at the study center between 2020 and 2025
* Available clinical and biochemical records, including referral indication
Exclusion Criteria
* Insufficient clinical information in medical records
* Patients with underlying conditions unrelated to bone health that preclude accurate evaluation (e.g., major skeletal deformities interfering with DEXA interpretation)
12 Years
21 Years
FEMALE
No
Sponsors
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Bagcilar Training and Research Hospital
OTHER_GOV
Responsible Party
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Nursen Kurtoglu Aksoy
Obstetrics and Gynecology Specialist, Bagcilar Training and Research Hospital
Principal Investigators
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Nursen Kurtoglu
Role: PRINCIPAL_INVESTIGATOR
Bagcilar Training and Research Hospital
Locations
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Bagcilar Training and Research Hospital
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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2025/05/05/048
Identifier Type: -
Identifier Source: org_study_id
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