Neuromusculoskeletal Alterations After ACL Injury

NCT ID: NCT07163468

Last Updated: 2025-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-01

Study Completion Date

2025-08-01

Brief Summary

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This study investigated how anterior cruciate ligament (ACL) injuries affect not only the knee joint but also brain activity, reaction speed, and psychological readiness to return to sports. A total of 60 male athletes, aged 18 to 30 years, were evaluated in three groups: healthy athletes, athletes who had undergone primary ACL reconstruction, and athletes who had undergone revision ACL reconstruction.

The study measured brain activity with electroencephalography (EEG), reaction time with a computer-based test, and psychological status with standardized questionnaires. The findings showed that athletes with revision ACL surgery had more difficulties in attention control, slower reaction times, and greater psychological barriers compared to the other groups.

These results suggest that ACL injuries and surgeries may influence not only physical recovery but also brain function and psychological readiness. The study highlights the importance of considering neuromuscular, cognitive, and emotional aspects when planning rehabilitation and return-to-sport decisions.

Detailed Description

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Conditions

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Anterior Cruciate Ligament Injuries Sports Injury Neurocognitive Function

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy Control Group

Athletes with no history of knee injury or surgery (n=20).

No interventions assigned to this group

Primary ACL Reconstruction Group

Athletes who had undergone a single ACL reconstruction, with rehabilitation completed at least 6 months prior to enrollment (n=20).

No interventions assigned to this group

Revision ACL Reconstruction Group

Athletes who had undergone at least two ACL surgeries including revision, with rehabilitation completed at least 6 months prior to enrollment (n=20).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Male athletes

Age between 18 and 30 years

Regular participation in amateur or professional sports

Completion of ACL rehabilitation (for surgical groups) at least 6 months before enrollment

Ability to undergo EEG and reaction time testing

Provision of signed informed consent

Exclusion Criteria

History of neurological or psychiatric conditions (e.g., epilepsy, ADHD, depression)

Additional lower extremity injuries or orthopedic surgeries

Metal implants or scalp conditions incompatible with EEG

Uncorrected visual or auditory deficits

Systemic illnesses (e.g., diabetes, multiple sclerosis, neuropathy)

Use of psychoactive medication

Any cognitive or physical limitation interfering with testing procedures

Female participants (to avoid hormonal confounding effects on EEG recordings)
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Duzce University

OTHER

Sponsor Role lead

Responsible Party

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Veysel Uludag

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Duzce University

Düzce, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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2025/177

Identifier Type: -

Identifier Source: org_study_id

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