Long-Term Safety of Pirtobrutinib in Participants With Previously Treated Types of Blood Cancers

NCT ID: NCT07162181

Last Updated: 2026-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-07

Study Completion Date

2030-05-31

Brief Summary

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The purpose of this study is to find out more about the long-term safety of pirtobrutinib in participants with previously treated types of blood cancer. Participants must have chronic lymphocytic leukemia, small lymphocytic lymphoma, or non-Hodgkins lymphoma. The study is open to those who completed the original study - J2N-MC-JZNJ (NCT04849416) and continue to benefit from treatment. Treatment will be given every 12 weeks and this study is expected to last about 5 years.

Detailed Description

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Conditions

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Lymphoma, Non-Hodgkin Leukemia, Lymphocytic, Chronic, B-Cell B-cell Lymphoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Pirtobrutinib

Pirtobrutinib administered orally.

Group Type EXPERIMENTAL

Pirtobrutinib

Intervention Type DRUG

Administered orally.

Interventions

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Pirtobrutinib

Administered orally.

Intervention Type DRUG

Other Intervention Names

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Loxo-305 LY3527727

Eligibility Criteria

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Inclusion Criteria

* Currently enrolled and active in the originator study, JZNJ. A participant is considered active in the study if they are receiving study intervention
* Agree to comply with contraception requirements. Contraceptive use by participants should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies

Exclusion Criteria

* Are pregnant, or intend to become pregnant during the study, or within 30 days of last dose of study treatment or to breastfeed during the study or within 1 week of the last dose of study treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Beijing Cancer hospital

Beijing, , China

Site Status NOT_YET_RECRUITING

Sun Yat-sen University Cancer Center

Guangzhou, , China

Site Status NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital

Harbin, , China

Site Status NOT_YET_RECRUITING

Shanghai East Hospital

Shanghai, , China

Site Status ACTIVE_NOT_RECRUITING

Blood Institute of the Chinese Academy of Medical science

Tianjin, , China

Site Status NOT_YET_RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Role: CONTACT

1-317-615-4559

Physicians interested in becoming principal investigators please contact

Role: CONTACT

Facility Contacts

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Role: primary

8613683398726

Role: primary

862087343355

Role: primary

8613313612989

Role: primary

8615900265415

Role: primary

8615871725926

Other Identifiers

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J2N-MC-JZ02

Identifier Type: OTHER

Identifier Source: secondary_id

2024-517760-29-00

Identifier Type: CTIS

Identifier Source: secondary_id

J2N-MC-JZNY

Identifier Type: OTHER

Identifier Source: secondary_id

J2N-MC-JZNJ

Identifier Type: OTHER

Identifier Source: secondary_id

27295

Identifier Type: -

Identifier Source: org_study_id

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