A Phase II Trial of the Safety and Efficacy of RSS0309 Ointment in Adults With Atopic Dermatitis

NCT ID: NCT07158151

Last Updated: 2025-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

168 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-25

Study Completion Date

2026-05-31

Brief Summary

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This study is ongoing to explore the efficacy and safety of different strengths of RSS0393 ointment in adults with atopic dermatitis

Detailed Description

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Conditions

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Atopic Dermatitis of Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Treatment group 1: RSS0393 ointment 0.05%

Group Type EXPERIMENTAL

RSS0393 ointment

Intervention Type DRUG

RSS0393 ointment 0.05%

Treatment group 2: RSS0393 ointment 0.01%

Group Type EXPERIMENTAL

RSS0393 ointment

Intervention Type DRUG

RSS0393 ointment 0.01%

Treatment group 3: RSS0393 ointment 0.03%

Group Type EXPERIMENTAL

RSS0393 ointment

Intervention Type DRUG

RSS0393 ointment 0.03%

Treatment group 4: RSS0393 ointment placebo

Group Type SHAM_COMPARATOR

RSS0393 ointment

Intervention Type DRUG

RSS0393 ointment placebo

Interventions

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RSS0393 ointment

RSS0393 ointment 0.05%

Intervention Type DRUG

RSS0393 ointment

RSS0393 ointment 0.01%

Intervention Type DRUG

RSS0393 ointment

RSS0393 ointment 0.03%

Intervention Type DRUG

RSS0393 ointment

RSS0393 ointment placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Age ≥18 years old and ≤75 years old at screening.
2. History of atopic dermatitis ≥ 6 months.
3. BSA is between 3% and 20% (inclusive) and EASI score is ≥ 5 and vIGA-AD is 2 or 3.
4. The subjects signed informed consent before any study-related procedures began.

Exclusion Criteria

1. Diagnosis of other dermatologic diseases at screening.
2. Subjects have other skin diseases or conditions that may affect the evaluation of the relevant endpoints of this study.
3. Subjects with any other persistent active autoimmune disease.
4. Subjects who have received topical medication for psoriasis within 14 days before baseline, or systemic medication or phototherapy for psoriasis within 28 days before baseline, or biological agents for psoriasis within a specified time before baseline.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Reistone Biopharma Company Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Dermatology Hospital of Southern Medical University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zeting Pan

Role: CONTACT

18814090443

Other Identifiers

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RSS0393Oint-202

Identifier Type: -

Identifier Source: org_study_id

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