Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure

NCT ID: NCT07155421

Last Updated: 2025-12-04

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-11-10
• Study Completion Date: 2025-12-31

Brief Summary

Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction. ADHF often results in reduced physical and respiratory capacity, greater dependence on oxygen support, difficulty performing daily activities, and prolonged hospital stays. In recent years, early exercise-based cardiopulmonary rehabilitation (CPR) has been introduced as part of heart failure management. Evidence suggests that early CPR improves overall health and cardiac function in heart failure patients. However, data regarding its effects in ADHF remain limited. While some studies indicate that early CPR enhances physical function, its impact on respiratory parameters and clinical outcomes is less well established.

Cardiopulmonary rehabilitation is a multidisciplinary program designed to promote physical, psychological, and social recovery in patients with cardiovascular and pulmonary diseases. It includes exercise training, education, psychosocial support, and behavioral strategies. Early CPR specifically aims to improve cardiovascular and respiratory functions in heart failure patients. Initiating CPR in the early phase of ADHF may accelerate recovery, strengthen cardiopulmonary function, shorten hospitalization, and improve quality of life.

This study aims to evaluate the effects of early CPR on functional capacity, hemodynamic parameters, and respiratory parameters in patients with ADHF.

Conditions

Heart Failure

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Early cardiopulmonary rehabilitation group

Exercise-based cardiopulmonary rehabilitation will be applied to this group during the hospital stay every day for 3 times a day.

Group Type: EXPERIMENTAL

Early Cardiopulmonary Rehabilitation

Intervention Type: OTHER

An individualized CPR program including positioning, deep breathing exercises (diaphragmatic and segmental breathing exercises), pursed-lip breathing exercises, breathing exercises using incentive spirometry, and progressive mobilization exercises (in-bed range of motion exercises, sitting, standing, and walking exercises)

Routine in-hospital care

Intervention Type: OTHER

Routine in-hospital care for acute decompansated heart failure

Control Group

Routine in-hospital care will be applied to this group.

Group Type: OTHER

Routine in-hospital care

Intervention Type: OTHER

Routine in-hospital care for acute decompansated heart failure

Interventions

Early Cardiopulmonary Rehabilitation

An individualized CPR program including positioning, deep breathing exercises (diaphragmatic and segmental breathing exercises), pursed-lip breathing exercises, breathing exercises using incentive spirometry, and progressive mobilization exercises (in-bed range of motion exercises, sitting, standing, and walking exercises)

Intervention Type: OTHER

Routine in-hospital care

Routine in-hospital care for acute decompansated heart failure

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients hospitalized with a diagnosis of acute decompensated heart failure
• Being clinically stable

Exclusion Criteria

• Having diagnosed pulmonary, neurological, renal, liver, gastrointestinal, orthopedic or oncological pathologies
• Having cardiomyopathy or congestive pericarditis
• Recent heart surgery in the past 6 months
• New or suspected thromboembolic event
• Presence of open wounds, ulcerations or major dermatological diseases in the lower extremities

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Istanbul University - Cerrahpasa

OTHER

Sponsor Role: collaborator

Saglik Bilimleri Universitesi

OTHER

Sponsor Role: collaborator

Yeditepe University

OTHER

Sponsor Role: collaborator

Izmir Bakircay University

OTHER

Sponsor Role: lead

Responsible Party

Melih Zeren

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Istanbul University- Cerrahpasa, Cardiology Institute

Istanbul, , Turkey (Türkiye)

Site Status: RECRUITING

Countries

Turkey (Türkiye)

Central Contacts

Kiymet Muammer, PT, PhD

Role: CONTACT

kiymet.muammer@iuc.edu.tr

+90 552 2058527

Facility Contacts

Kiymet Muammer, PT, PhD

Role: primary

kiymet.muammer@iuc.edu.tr

+90 552 20585

Other Identifiers

bakircaymzeren09

Identifier Type: -

Identifier Source: org_study_id