Outcome of Use of a Novel Modulator of Oxidative Phosphorylation on Kidney Function in Patients With Progressive Chronic Kidney Disease

NCT ID: NCT07150338

Last Updated: 2025-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-20

Study Completion Date

2022-11-20

Brief Summary

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Outcome of use of a novel Modulator of Oxidative Phosphorylation on kidney function in patients with Chronic Kidney Disease

Detailed Description

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QRX-3 ( Eseronate ) is a formulated drug designed to supply and optimize NAD+ mitochondrial availability in order to target the loss of nephrons via renal fibrosis and tubular senescence of the kidney cells by enhancing the mitochondrial activity of these cells via the NAD/NAD+ redox pathway as well as reduce the presence of fibrogenic intracellular inflammatory markers . This novel drug therapy stabilized the intracellular oxidative phosphorylation process a pathway mechanism that is dysregulated or abnormal in the ongoing renal tubular cell injury and damage in chronic kidney disease.

In this study the investigators evaluate the effect of intervention with this novel drug therapy on a chronic kidney disease CKD population with slowly progressively declining renal function.

Conditions

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Chronic Kidney Disease (Stage 3-4) Chronic Kidney Disease (Stages 4 and 5) Proteinuria

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patient with progressive chronic kidney disease

GFR decline

QRX-3

Intervention Type DRUG

Compounded new drug regime

Eseronate

Intervention Type DRUG

Neukidney innovative drug

Interventions

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QRX-3

Compounded new drug regime

Intervention Type DRUG

Eseronate

Neukidney innovative drug

Intervention Type DRUG

Other Intervention Names

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QRX-3

Eligibility Criteria

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Inclusion Criteria

* Patient with Chronic kidney disease
* Estimated Glomerular function by MDRD of less than 60mls/min
* Patients with declining renal function ( as measured by eGFR by MDRD )
* Rate of decline of eGFR over the last one year of less than 20%
* Negative Serology markers for CKD etiology
* Provider perceived adherence to study follow up

Exclusion Criteria

* • Rapid rate of decline in kidney function of \> 20 % over last one year

* Symptomatic renal failure
* Presence of any suspected Acute renal failure superimposed
* Presence of cast , hematuria, or abnormal urinalysis outside of simple UTI
* No known reversible cause of renal decline
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Neukidney Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Ebima Clifford Okundaye

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ebima okundaye, MD

Role: PRINCIPAL_INVESTIGATOR

Neukidney Inc.

Locations

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Premier Kidney clinic

Pasadena, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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0001A

Identifier Type: -

Identifier Source: org_study_id

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