Healing Effect of Tea Tree Oil on Burn

NCT ID: NCT07149844

Last Updated: 2025-09-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-07-02
• Study Completion Date: 2023-09-22

Brief Summary

Tea tree oil (TTO) has been recognized for its effectiveness in treating infected burns, insect bites, and promoting wound healing. This clinical study aimed to compare the impact of Tea tree oil dressings versus conventional ones in the healing process of second degree burns wounds.

Detailed Description

This quasi-experimental comparative controlled clinical trial was conducted at the Burn Unit of Ras-Elteen General Hospital in Alexandria, Egypt. A purposive sample of 30 adult patients with second-degree burns on the chest, abdomen, upper limbs (excluding hands), and lower limbs (excluding feet) was enrolled from the Emergency and Outpatient Departments. Participants were sequentially assigned to two equal groups:

Control group (n=15): Received conventional dressings (sterile gauze with silver sulfadiazine).

Study group (n=15): Received topical 10% tea tree oil (TTO) ointment applied directly to wounds.Wounds were cleansed with sterile normal saline (0.9%), and non-viable tissue was debrided.

Dressings were changed every other day unless soiled or damp. Burns near joints were maintained in functional positions.Wound assessment was performed on days 7, 14, and 21 post-treatment

Conditions

Burn

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

conventional dressing

Conventional dressing: Is the routine study hospital's burn dressing technique, utilizing sterile topical gauze dressing that is impregnated with or laid over a topical antibacterial, silver sulphadiazin dressing secured with adhesive tape.

Group Type: OTHER

tea tree oil ointment

Intervention Type: DRUG

Petrolatum (petroleum jelly) was sterilized in the oven at 160°C for 90 min, then The ointment was prepared as 10% .

Interventions

tea tree oil ointment

Petrolatum (petroleum jelly) was sterilized in the oven at 160°C for 90 min, then The ointment was prepared as 10% .

Intervention Type: DRUG

Other Intervention Names

فtea tree ointment

Eligibility Criteria

Inclusion Criteria

• Patient willing to participate and communicate
• Newly admitted with recent 2nd-degree burns (superficial or deep) involving ≤10% of TBSA
• Length of hospital stay of 10 days

Exclusion Criteria

Any associated illnesses that may affect wound healing, such as:

• Diabetes mellitus (DM)
• Immune disorders
• Pre-existing skin conditions (e.g., eczema)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Alexandria University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

hoda fathy, prof

Role: PRINCIPAL_INVESTIGATOR

Alexandria University

Locations

Ras Eltin Hospital

Alexandria, , Egypt

Countries

Egypt

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

1482025

Identifier Type: -

Identifier Source: org_study_id