The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy

NCT ID: NCT07140991

Last Updated: 2025-08-26

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 102 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-06-01
• Study Completion Date: 2025-08-20

Brief Summary

Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality. Patients with older age and comorbidities have a higher risk of death following anastomotic leakage.

Perioperative hyperglycemia is frequently observed in patients undergoing major abdominal surgery as a stress response to surgical trauma, leading to surgical complications through mechanisms such as glycogenolysis, lipolysis, gluconeogenesis, decreased insulin sensitivity, and increased insulin resistance. Hyperglycemia is known to increase the risk of postoperative infection, prolong hospital stay, and increase mortality. Additionally, recent studies have shown that it also increases the risk of anastomotic leakage.

Detailed Description

Although diabetes mellitus is a known risk factor for anastomotic leaks, there are few studies on the relationship between perioperative hyperglycemia and anastomotic leaks. The primary objective of our study was to demonstrate the relationship between hyperglycemia detected during anastomosis formation in the perioperative period and postoperative anastomotic leaks.

Conditions

Hyperglycaemia; Total Gastrectomy; Anastomotic Leaks

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

hyperglycemia

Patients identified as hyperglycemic in the perioperative period

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• elective total gastrectomy
• anastomotic leak after surgery
• age 18-75

Exclusion Criteria

• emergency procedure
• <18 years
• >75 years
• ASA score > 3

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Taner Abdullah

OTHER

Sponsor Role: lead

Responsible Party

Taner Abdullah

MD

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Mustafa Çağrı Temel, MD

Role: PRINCIPAL_INVESTIGATOR

Basaksehir Cam ve Sakura State Hospital

Locations

Basaksehir Cam ve Sakura City Hospital

Istanbul, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

2025-183

Identifier Type: -

Identifier Source: org_study_id