Prospective Observatonal Study for Effect of Duodenojejunal Bypass and Gastric Bypass on T2DM Patients

NCT ID: NCT01735253

Last Updated: 2012-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-12-31

Study Completion Date

2012-10-31

Brief Summary

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Surgical treatment for type 2 diabetes has been taken note especially in less obese or non obese patients. In Asian, the nuber of less obses or non obese patients with T2DM is greater than that of the obese.

We are trying to do a prospective observational study for the evaluation of the effect of duidenojejunal bypass and gastric bypass on the glycemoc control in those patients.

The selection criteria are type 2 diabetess, 20-60 years old, BMI 23-34 or 21-22 with viceral obesity, insulin use less than 10 years and the patients understanding the hypothesis of this study, risks, expecting effects and agreeing this study.

We are checking oral GTT, insulin level, C-peptide level, HbA1C, etc. with some anthropometric measurs preoperatively, postoperatively, at 3 month and 12 month.

We will compare the clinical factors at each time.

Detailed Description

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Conditions

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Non Insulin Dependent Diabetes Mellitus

Keywords

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metabolic surgery gastric bypass duodenojejunal bypass type 2 DM

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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gastric bypass, duodenojejunal bypass

Group Type EXPERIMENTAL

laparoscopic roux en Y gastric bypass / open duodenojejunal bypass

Intervention Type PROCEDURE

routine GBP with 80cm roux and biliopancreatic limb

Interventions

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laparoscopic roux en Y gastric bypass / open duodenojejunal bypass

routine GBP with 80cm roux and biliopancreatic limb

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* type 2 diabetes
* HbA1C \> 7.0%
* BMI 23 - 34 or BMI 21-22 with viceral obesity
* insulin use less than 10 years
* uncerstanding the risks, hypothesis, expecting effects

Exclusion Criteria

* type 1 diabetes
* C-peptide \< 1.0ng/ml
* BMI \< 21
* severe cardiovascular diseases or their history
* malignancy or history
* alcoholics, pituitary failrue
* history of severe ketosis, diabetic coma or precoma
* abnormal liver enzyme, over 3 fold of normal level
* liver cirrhosis or hepatitis
* serum creatinine \> 2.0mg/dL
* glucocorticoids user
* diabetes due to other endocrine diseases
* pancreatic disease
* anti-GAD Ab (+)
* the incongruity for surgery
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Inha University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Inha University Hospital

IRB Inha University Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Yoonseok Heo

Incheon, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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inha 09-58

Identifier Type: -

Identifier Source: org_study_id