Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

NCT ID: NCT07133204

Last Updated: 2025-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-01

Study Completion Date

2025-07-20

Brief Summary

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The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.

The study is experimental clinical pilot study as a single group pretest-posttest.

A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

Detailed Description

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Conditions

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Hyperpigmentation; Melanin

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Study arm

Group Type EXPERIMENTAL

Investigator developed cream infused with HuangQin extract

Intervention Type OTHER

A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.

Interventions

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Investigator developed cream infused with HuangQin extract

A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or Female
* Has at least 1 hyperpigmentation spot (size \> 3mm) on either side of the face
* 30-60 y/o
* Fitzpatrick skin types II-IV
* Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study

Exclusion Criteria

* Pregnant or lactating
* Use of whitening products or treatment within 1 month before this study
* Currently using contraceptives
* History of allergy to any ingredient in the intervention cream
* Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
* Severe disease (i.e. immunodeficiency, cancer)
* Enrolled in other clinical study within 3 month before this study
Minimum Eligible Age

30 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Mae Fah Luang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chakree C Wattanasiri, RPh PhD

Role: PRINCIPAL_INVESTIGATOR

Mae Fah Luang University

Locations

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Mae Fah Luang University

Muang, Changwat Chiang Rai, Thailand

Site Status

Countries

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Thailand

Other Identifiers

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EC 24061-25

Identifier Type: -

Identifier Source: org_study_id

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