Acute Effects of Zynamite® S in Cognitive Function and Mood
NCT ID: NCT07126717
Last Updated: 2025-08-17
Study Results
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Basic Information
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COMPLETED
NA
88 participants
INTERVENTIONAL
2025-05-12
2025-06-09
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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Placebo
Capsule containing food-grade maltodextrin
Placebo
Food-grade maltodextrin
Zynamite® S 100mg
Capsule containing 100 mg of soluble mango leaf extract (Zynamite® S) standardized to 60% of mangiferin
Zynamite® S
Water-soluble mango leaf extract standardized to 60% of mangiferin
Interventions
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Placebo
Food-grade maltodextrin
Zynamite® S
Water-soluble mango leaf extract standardized to 60% of mangiferin
Eligibility Criteria
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Inclusion Criteria
* Being between 18 and 25 years old
* Being healthy and free of any relevant medical condition or illness
Exclusion Criteria
* Being pregnant or lactating
* Having any known intolerance, hypersensitivity, or allergies to any of the ingredients of the investigational products
* Having intestinal malabsorption problems, as well as learning difficulties, dyslexia, eye problems, or color blindness
* Intaking of psychoactive substances or medications that could influence the study results, such as consuming \>500 mg of caffeine per day (\>6 cups of 150 ml filtered coffee) and/or alcohol
* Having comprehension or communication difficulties that prevent full understanding of the informed consent or effective participation in the study, such as autism spectrum disorders, aphasia, or intellectual disability
18 Years
25 Years
ALL
Yes
Sponsors
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University of Atlántico Medio
UNKNOWN
Nektium Pharma SL
INDUSTRY
Responsible Party
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Locations
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University of Atlántico Medio
Tafira Baja, Las Palmas, Spain
Countries
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References
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Castellote-Caballero Y, Beltran-Arranz A, Aibar-Almazan A, Carcelen-Fraile MDC, Rivas-Campo Y, Lopez-Rios L, Vega-Morales T, Gonzalez-Martin AM. Acute Supplementation of Soluble Mango Leaf Extract (Zynamite(R) S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Pharmaceuticals (Basel). 2025 Apr 14;18(4):571. doi: 10.3390/ph18040571.
Fuentes-Rios D, Sanchez-Rodriguez A, Lopez-Rios L, Garcia-Gonzalez E, Martinez-Canton M, Galvan-Alvarez V, Gallego-Selles A, Martin-Rincon M, Calbet JAL, Vega-Morales T. Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation. Molecules. 2025 Jan 21;30(3):461. doi: 10.3390/molecules30030461.
Sharif S, Guirguis A, Fergus S, Schifano F. The Use and Impact of Cognitive Enhancers among University Students: A Systematic Review. Brain Sci. 2021 Mar 10;11(3):355. doi: 10.3390/brainsci11030355.
Malik M, Tlustos P. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. Nutrients. 2022 Aug 17;14(16):3367. doi: 10.3390/nu14163367.
Jangra A, Lukhi MM, Sulakhiya K, Baruah CC, Lahkar M. Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice. Eur J Pharmacol. 2014 Oct 5;740:337-45. doi: 10.1016/j.ejphar.2014.07.031. Epub 2014 Jul 23.
Cao C, Su M, Zhou F. Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model. Behav Pharmacol. 2017 Aug;28(5):356-364. doi: 10.1097/FBP.0000000000000305.
Lum PT, Sekar M, Gan SH, Pandy V, Bonam SR. Protective effect of mangiferin on memory impairment: A systematic review. Saudi J Biol Sci. 2021 Jan;28(1):917-927. doi: 10.1016/j.sjbs.2020.11.037. Epub 2020 Nov 13.
Lei LY, Wang RC, Pan YL, Yue ZG, Zhou R, Xie P, Tang ZS. Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-kappaB, NLRP3 pathway. Chin J Nat Med. 2021 Feb;19(2):112-119. doi: 10.1016/S1875-5364(21)60012-2.
Li HW, Lan TJ, Yun CX, Yang KD, Du ZC, Luo XF, Hao EW, Deng JG. Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway. Chin Herb Med. 2019 Dec 14;12(1):36-46. doi: 10.1016/j.chmed.2019.12.002. eCollection 2020 Jan.
Alberdi E, Sanchez-Gomez MV, Ruiz A, Cavaliere F, Ortiz-Sanz C, Quintela-Lopez T, Capetillo-Zarate E, Sole-Domenech S, Matute C. Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers. Oxid Med Cell Longev. 2018 Jun 14;2018:2856063. doi: 10.1155/2018/2856063. eCollection 2018.
Lopez-Rios L, Wiebe JC, Vega-Morales T, Gericke N. Central nervous system activities of extract Mangifera indica L. J Ethnopharmacol. 2020 Oct 5;260:112996. doi: 10.1016/j.jep.2020.112996. Epub 2020 May 27.
Wightman EL, Jackson PA, Forster J, Khan J, Wiebe JC, Gericke N, Kennedy DO. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients. 2020 Jul 23;12(8):2194. doi: 10.3390/nu12082194.
Other Identifiers
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ZYNS_HCT_2025.01
Identifier Type: -
Identifier Source: org_study_id
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