Trial Outcomes & Findings for Usability of the MeTime MS App (NCT NCT07123272)
NCT ID: NCT07123272
Last Updated: 2025-11-20
Results Overview
Qualitative descriptions of positive, negative, and neutral aspects of usability of the Me Time MS app, gathered through one-on-one, open-ended interviews after 6 weeks of access to the app. Results reflect the total number of comments across all participants that were provided for each category. Participants could submit multiple types of comments.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
10 participants
Primary outcome timeframe
Up to 2 weeks after the 6-week app usage period ended
Results posted on
2025-11-20
Participant Flow
Participant milestones
| Measure |
Relaxing Self-Acupressure
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: Relaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are:
1. Yin Tang (Unilaterally): Located on the forehead, between the eyebrows.
2. Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear.
3. Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky.
4. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
5. Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes.
|
Stimulating Self-Acupressure
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: There is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are:
1. Du 20 (Unilaterally): Located at the top of the head.
2. Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger.
3. Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline.
4. Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg.
5. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
6. Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle.
|
|---|---|---|
|
Overall Study
STARTED
|
5
|
5
|
|
Overall Study
COMPLETED
|
5
|
5
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Usability of the MeTime MS App
Baseline characteristics by cohort
| Measure |
Relaxing Self-Acupressure
n=5 Participants
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: Relaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are:
1. Yin Tang (Unilaterally): Located on the forehead, between the eyebrows.
2. Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear.
3. Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky.
4. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
5. Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes.
|
Stimulating Self-Acupressure
n=5 Participants
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: There is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are:
1. Du 20 (Unilaterally): Located at the top of the head.
2. Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger.
3. Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline.
4. Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg.
5. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
6. Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle.
|
Total
n=10 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
48 years
STANDARD_DEVIATION 7.65
|
54 years
STANDARD_DEVIATION 9.67 • n=4 Participants
|
51.00 years
STANDARD_DEVIATION 8.81 • n=8 Participants
|
|
Sex/Gender, Customized
Male
|
1 Participants
|
0 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Sex/Gender, Customized
Female
|
3 Participants
|
5 Participants
n=4 Participants
|
8 Participants
n=8 Participants
|
|
Sex/Gender, Customized
Prefer Not to Answer
|
1 Participants
|
0 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
5 Participants
|
5 Participants
n=4 Participants
|
10 Participants
n=8 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Asian
|
1 Participants
|
0 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Race (NIH/OMB)
White
|
4 Participants
|
4 Participants
n=4 Participants
|
8 Participants
n=8 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Region of Enrollment
United States
|
5 Participants
|
5 Participants
n=4 Participants
|
10 Participants
n=8 Participants
|
|
Education Level
High school graduate
|
1 Participants
|
0 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Education Level
Associates/Technical Degree
|
2 Participants
|
1 Participants
n=4 Participants
|
3 Participants
n=8 Participants
|
|
Education Level
Some college, No Degree
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Education Level
Bachelor's Degree
|
1 Participants
|
2 Participants
n=4 Participants
|
3 Participants
n=8 Participants
|
|
Education Level
Master's Degree
|
1 Participants
|
1 Participants
n=4 Participants
|
2 Participants
n=8 Participants
|
|
Employment Status
Disabled
|
3 Participants
|
2 Participants
n=4 Participants
|
5 Participants
n=8 Participants
|
|
Employment Status
Working Part time
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Employment Status
Working Full Time
|
2 Participants
|
2 Participants
n=4 Participants
|
4 Participants
n=8 Participants
|
|
Multiple sclerosis (MS) Subtype
Relapsing-Remitting Multiple Sclerosis
|
4 Participants
|
3 Participants
n=4 Participants
|
7 Participants
n=8 Participants
|
|
Multiple sclerosis (MS) Subtype
Primary Progressive Multiple Sclerosis
|
1 Participants
|
1 Participants
n=4 Participants
|
2 Participants
n=8 Participants
|
|
Multiple sclerosis (MS) Subtype
Secondary Progressive Multiple Sclerosis
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Mobility aid
Walk without assistance
|
2 Participants
|
2 Participants
n=4 Participants
|
4 Participants
n=8 Participants
|
|
Mobility aid
Cane/Walker
|
3 Participants
|
1 Participants
n=4 Participants
|
4 Participants
n=8 Participants
|
|
Mobility aid
Manual Wheelchair
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Mobility aid
Participant Did Not Respond
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Normal
|
1 Participants
|
0 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Mild Disability
|
1 Participants
|
1 Participants
n=4 Participants
|
2 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Moderate Disability
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Gait Disability
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Early cane
|
2 Participants
|
1 Participants
n=4 Participants
|
3 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Late Cane
|
1 Participants
|
1 Participants
n=4 Participants
|
2 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Bilateral Support
|
0 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=8 Participants
|
|
Patient-determined Disease Steps (PDDS)
Wheelchair/Scooter
|
0 Participants
|
1 Participants
n=4 Participants
|
1 Participants
n=8 Participants
|
PRIMARY outcome
Timeframe: Up to 2 weeks after the 6-week app usage period endedPopulation: 3 participants in the Stimulating arm did not attend an interview.
Qualitative descriptions of positive, negative, and neutral aspects of usability of the Me Time MS app, gathered through one-on-one, open-ended interviews after 6 weeks of access to the app. Results reflect the total number of comments across all participants that were provided for each category. Participants could submit multiple types of comments.
Outcome measures
| Measure |
Relaxing Self-Acupressure
n=59 Comments
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: Relaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are:
1. Yin Tang (Unilaterally): Located on the forehead, between the eyebrows.
2. Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear.
3. Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky.
4. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
5. Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes.
|
Stimulating Self-Acupressure
n=21 Comments
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: There is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are:
1. Du 20 (Unilaterally): Located at the top of the head.
2. Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger.
3. Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline.
4. Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg.
5. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
6. Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle.
|
|---|---|---|
|
Participant Perception of Me Time MS App Usability
Positive
|
37 Comments
|
11 Comments
|
|
Participant Perception of Me Time MS App Usability
Negative
|
9 Comments
|
4 Comments
|
|
Participant Perception of Me Time MS App Usability
Neutral
|
13 Comments
|
6 Comments
|
SECONDARY outcome
Timeframe: Up to 2 weeks after the 6-week app usage period endedPopulation: 3 participants in the Stimulating Arm did not complete the SUS survey.
SUS is a custom, 10-item survey to assess the participant's perception of the usability of the MeTime MS app. Possible total score ranges from 0 (lowest usability) to 40 (highest usability).
Outcome measures
| Measure |
Relaxing Self-Acupressure
n=5 Participants
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: Relaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are:
1. Yin Tang (Unilaterally): Located on the forehead, between the eyebrows.
2. Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear.
3. Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky.
4. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
5. Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes.
|
Stimulating Self-Acupressure
n=2 Participants
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: There is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are:
1. Du 20 (Unilaterally): Located at the top of the head.
2. Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger.
3. Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline.
4. Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg.
5. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
6. Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle.
|
|---|---|---|
|
System Usability Scale (SUS) Adapted for the MeTime MS App
|
35.8 score on a scale
Standard Deviation 2.28
|
29.5 score on a scale
Standard Deviation 6.36
|
Adverse Events
Relaxing Self-Acupressure
Serious events: 0 serious events
Other events: 4 other events
Deaths: 0 deaths
Stimulating Self-Acupressure
Serious events: 0 serious events
Other events: 1 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
| Measure |
Relaxing Self-Acupressure
n=5 participants at risk
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: Relaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are:
1. Yin Tang (Unilaterally): Located on the forehead, between the eyebrows.
2. Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear.
3. Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky.
4. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
5. Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes.
|
Stimulating Self-Acupressure
n=5 participants at risk
Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks.
Self-guided smartphone application for relaxing acupressure: There is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are:
1. Du 20 (Unilaterally): Located at the top of the head.
2. Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger.
3. Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline.
4. Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg.
5. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
6. Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle.
|
|---|---|---|
|
General disorders
Fatigue
|
20.0%
1/5 • Up to 8 weeks
|
20.0%
1/5 • Up to 8 weeks
|
|
Nervous system disorders
Cramping
|
20.0%
1/5 • Up to 8 weeks
|
0.00%
0/5 • Up to 8 weeks
|
|
General disorders
Soreness
|
40.0%
2/5 • Up to 8 weeks
|
0.00%
0/5 • Up to 8 weeks
|
|
Nervous system disorders
Difficulty with certain acupoints due to limited mobility
|
20.0%
1/5 • Up to 8 weeks
|
20.0%
1/5 • Up to 8 weeks
|
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place