Evaluating the Impact of CONNECT in a Multilingual Population

NCT ID: NCT07111936

Last Updated: 2025-08-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

439 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2028-03-31

Brief Summary

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This study aims to broaden the reach of the lung cancer screening (LCS) CONNECT program (NCT04149249, NCT06213532), by developing a version of the program to be available to multilingual communities. The CONNECT program encourages individuals who are undergoing lung cancer screening to also quit smoking by providing a personalized program which includes a video doctor with personalized responses, text message and telephone call support and connection with a pharmacist to assist in obtaining nicotine replacement medication. This clinical trial will develop and ultimately test how well the CONNECT Multilingual (CONNECT ML) program works to improve smoking cessation among current adult smokers within the Spanish and Cantonese speaking communities.

Detailed Description

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PRIMARY OBJECTIVES:

I. Culturally adapt, translate, improve and fine tune the multi-faceted CONNECT program for multilingual smokers

II. Evaluate the CONNECT multilingual program for current smokers in multilingual communities.

III. Assess the impact of the CONNECT Multilingual program on smoking cessation rates and participant utilization of evidence-based resources to help quit smoking

OUTLINE:

FOCUS GROUP (N=24):

Three focus groups, one each with English, Spanish and Cantonese speaking participants (8 in each group) will be led by investigators. Interviews will be recorded, transcribed and translated. Translation of the Spanish and Cantonese transcripts will be done by University of California, San Francisco (UCSF) translation services.

BETA GROUP (N=15):

The investigators will conduct a pilot, beta testing of the intervention materials with English, Spanish and Cantonese speaking participants. Additional feedback and input from the participants will be used to fine tune the CONNECT smoking cessation intervention to be implemented in a randomized trial.

RANDOMIZED CONTROLLED TRIAL (N=400):

Newly enrolled participants will be assigned to 1 of 2 conditions.

* Group 1: Participants receive the CONNECT Multilingual intervention. Participants will be followed up at 1-week, 1-, 3-, and 6-months after treatment assignment. At 6-months, participants will be asked to complete and return an at-home saliva kit to verify their smoking status.
* Group 2: Participants receive usual care from providers at a regular primary care appointment. Participants will be followed up at 1-week, 1-, 3-, and 6-months after treatment assignment.

Conditions

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Smoking Cessation Smoking Cessation Counseling Ability and Practice Smoking Cessation Counselling Lung Cancer Screening

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

Participants will be enrolled in the focus group. Once completed, new participants will be enrolled in the beta group. After interim analysis has been completed, new participants will be enrolled in the randomized arms.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Focus Group

Participants in the focus group will be interviewed by the study staff and discuss barriers and facilitators to smoking cessation to be implemented in the beta and randomized phases of the study.

Group Type OTHER

Interview

Intervention Type OTHER

Attend a focus group

Beta Group

Participants will be testing the CONNECT multilingual smoking cessation materials and provide feedback to investigators. Participation will be limited to about 1.5 - 2 hours.

Group Type ACTIVE_COMPARATOR

CONNECT Intervention for multilingual populations

Intervention Type BEHAVIORAL

The program includes interactive Video Doctor visits to provide participants with information tailored to their individual responses and outreach via brief telephone calls and text messaging to follow-up and connect smokers with evidence-based resources for smoking cessation.

Group 1: CONNECT Multi-lingual intervention

Participants receive the CONNECT multilingual smoking cessation intervention finalized in the beta group analysis, that includes multi-lingual interactive video doctor intervention, text messages once weekly for 12 weeks, and several telephone counseling calls. Participants also receive access to a pharmacist to receive counseling about quitting smoking and may prescribe nicotine replacement therapy. Participants will be asked to provide a saliva sample at the end of the study

Group Type EXPERIMENTAL

CONNECT Intervention for multilingual populations

Intervention Type BEHAVIORAL

The program includes interactive Video Doctor visits to provide participants with information tailored to their individual responses and outreach via brief telephone calls and text messaging to follow-up and connect smokers with evidence-based resources for smoking cessation.

Saliva Sample

Intervention Type OTHER

Undergo saliva collection

Group 2: Control Group

Participants will receive usual care for smoking cessation at routine medical visit and be asked to complete a total of four brief follow-up phone surveys. Participants will be asked to provide a saliva sample at the end of the study.

Group Type EXPERIMENTAL

Saliva Sample

Intervention Type OTHER

Undergo saliva collection

Interventions

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CONNECT Intervention for multilingual populations

The program includes interactive Video Doctor visits to provide participants with information tailored to their individual responses and outreach via brief telephone calls and text messaging to follow-up and connect smokers with evidence-based resources for smoking cessation.

Intervention Type BEHAVIORAL

Saliva Sample

Undergo saliva collection

Intervention Type OTHER

Interview

Attend a focus group

Intervention Type OTHER

Other Intervention Names

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CONNECT Multilingual program Saliva Sample collection

Eligibility Criteria

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Inclusion Criteria

* Age 50-80 years old.
* Current smokers defined at smoking at least one cigarette in past 7 days AND eligible for lung cancer screening (LCS) based on smoking history (\>=20 pack year history)
* California (CA) residents
* Able to understand and comply with study procedures for the entire length of the study.
* Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it.

Exclusion Criteria

* Non-smokers.
* Individuals with a diagnosis of lung cancer.
* Individuals receiving hospice care.
* Individuals whose providers do not think that they should participate (e.g., psychiatric illness or significant cognitive impairment that would impede the individuals ability to participate).
* Hearing and/or vision disabilities that would prevent participants from adequately receiving treatment components such as video or telephone counseling.
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tobacco Related Disease Research Program

OTHER

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Judith Walsh, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Locations

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University of California San Francisco

San Francisco, California, United States

Site Status

Countries

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United States

Central Contacts

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Anita Ponce, MSc

Role: CONTACT

415-502-1317

Facility Contacts

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Anita Ponce, MSc

Role: primary

415-502-1317

Other Identifiers

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NCI-2025-05153

Identifier Type: REGISTRY

Identifier Source: secondary_id

25635

Identifier Type: -

Identifier Source: org_study_id

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