Scheduled Autologous PRP Guided Injection in the Maxillary Bony Defects

NCT ID: NCT07108933

Last Updated: 2025-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-15

Study Completion Date

2025-04-15

Brief Summary

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Scheduled autologous platelet-rich plasma guided injection is done in critical-sized maxillary bony defects after surgical excision of non- malignant lesions.

Detailed Description

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The study aims to detect the effect of scheduled autologous platelet-rich plasma- guided injection in the healing process of critical-sized maxillary bony defects after surgical removal of non-malignant lesions by using bone volumetric analysis and density measuring with cone beam computed tomography.

Conditions

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Bony Defect

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Randomized Clinical Trial (RCT)
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

No masking

Study Groups

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Injection

Scheduled injection of autologous platelet-rich plasma

Group Type OTHER

Autologous platelet-rich plasma

Intervention Type BIOLOGICAL

Guided injection of PRP in bony cavities of maxilla after surgical excision of non-malignant tumors.

Interventions

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Autologous platelet-rich plasma

Guided injection of PRP in bony cavities of maxilla after surgical excision of non-malignant tumors.

Intervention Type BIOLOGICAL

Other Intervention Names

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PRP

Eligibility Criteria

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Inclusion Criteria

* Age: 18-65 years (adults within a specific age range).

Diagnosis: Non-malignant maxillary bony defects (e.g., benign tumors or cysts).

Health: Generally healthy participants who can tolerate surgery.

Platelet Function: No platelet disorders or blood-related conditions.

Willingness: Informed consent and ability to follow the protocol.

No Use of Blood Thinners: No current use of anticoagulants like aspirin.

Exclusion Criteria

* Age: Children (under 18) and elderly (over 75).

Malignant Lesions: Participants with cancer or pre-cancerous conditions.

Systemic Illness: Severe conditions (e.g., uncontrolled diabetes, autoimmune disorders).

Platelet Disorders: Low platelet count or bleeding disorders (e.g., hemophilia).

Infections: Active infections or inflammatory conditions (e.g., periodontal disease).

Pregnancy: Women who are pregnant or breastfeeding.

Recent Surgery/Trauma: Recent maxillary surgery or trauma.

Uncontrolled Medications: Use of blood thinners, NSAIDs, or immunosuppressive drugs.

Non-compliance: Unwillingness or inability to follow-up with the protocol.

Substance Abuse: Active drug or alcohol abuse.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Horus University

OTHER

Sponsor Role lead

Responsible Party

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Eman Abdel Salam Yousef

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Eman Abdel Salam, Prof

Role: STUDY_DIRECTOR

Head of department of Oral Surgery

Locations

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Dental clinics of Aswan University Hospital

Aswān, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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PRP in maxillary bone defects

Identifier Type: -

Identifier Source: org_study_id

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