Enhanced Recovery After Surgery (ERAS) Protocol in Elective Cesarean Sections

NCT ID: NCT07104890

Last Updated: 2025-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-01

Study Completion Date

2022-12-01

Brief Summary

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This study evaluates the effect of the Enhanced Recovery After Surgery (ERAS) protocol on early postoperative recovery in women undergoing elective cesarean section.

Eighty-four pregnant women, aged 18 years or older, at 37 weeks of gestation or beyond, without chronic medical conditions, and classified as ASA I-II, were enrolled. Participants were randomly assigned to either:

ERAS group - received the ERAS protocol, including early oral intake, early mobilization, multimodal analgesia, and enhanced perioperative care

Control group - received standard perioperative cesarean section care

The study compared breastfeeding initiation time, gas passage, oral intake, mobilization time, and postoperative pain scores (VAS) between the two groups.

The aim is to determine whether ERAS can accelerate recovery, reduce pain, and improve maternal comfort after elective cesarean delivery.

Detailed Description

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Enhanced Recovery After Surgery (ERAS) protocols aim to accelerate postoperative recovery, reduce complications, and shorten hospital stays. While ERAS has been widely implemented in general and gynecologic surgeries, its application in obstetric surgery, particularly elective cesarean delivery, remains limited.

This single-center, prospective, randomized clinical trial was conducted at the University of Health Sciences, Istanbul Gaziosmanpasa Training and Research Hospital, between October 2022 and December 2022. Eighty-four women scheduled for elective cesarean section were enrolled. Eligible participants were 18 years or older, at ≥37 weeks of gestation, ASA I-II, without chronic comorbidities, and provided written informed consent.

Participants were randomized (1:1) into two groups:

ERAS group: Managed with ERAS protocol including early oral intake, early mobilization, multimodal analgesia with opioid-sparing strategies, prophylactic antiemetics, early urinary catheter removal, and gum chewing to stimulate bowel function.

Control group: Managed with standard perioperative cesarean care including delayed oral intake, standard pain management, and later mobilization.

Primary outcomes included breastfeeding initiation time, gas passage, time to oral intake, mobilization time, and postoperative pain scores (VAS at 24 and 48 hours). Secondary outcomes included nausea-vomiting incidence and overall postoperative recovery profile.

The study aims to determine whether ERAS protocols improve postoperative recovery and patient comfort after elective cesarean section and to support the implementation of ERAS as a standard in obstetric surgery.

Conditions

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Elective Cesarean Section Postoperative Recovery Enhanced Recovery After Surgery (ERAS)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This is a single-center, prospective, randomized, parallel-group clinical trial.

Participants were randomly assigned in a 1:1 ratio to either the ERAS protocol group or the standard care control group.

Both groups were followed concurrently for postoperative recovery outcomes after elective cesarean section.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ERAS Protocol Group

Participants in this arm will receive the Enhanced Recovery After Surgery (ERAS) protocol during elective cesarean section. The ERAS protocol includes early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early urinary catheter removal, and gum chewing to stimulate bowel function. Postoperative outcomes such as breastfeeding initiation, gas passage, oral intake time, mobilization, and VAS pain scores will be evaluated.

Group Type EXPERIMENTAL

Enhanced Recovery After Surgery (ERAS) Protocol, which includes early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early urinary catheter removal, an

Intervention Type BEHAVIORAL

The Enhanced Recovery After Surgery (ERAS) Protocol for elective cesarean section includes a multimodal perioperative care approach aimed at accelerating postoperative recovery. Key components are early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early removal of the urinary catheter, and gum chewing to stimulate bowel function. This protocol is compared with Standard Perioperative Cesarean Care, which involves overnight fasting, delayed oral intake until bowel function returns, conventional analgesia, later mobilization, and routine catheter removal.

Standard Care Group

Participants in this arm will receive standard perioperative cesarean care, which includes overnight fasting, delayed oral intake until gas passage, routine analgesia with paracetamol, NSAIDs and opioids as needed, later urinary catheter removal, and routine postoperative mobilization. Outcomes will be assessed similarly to the ERAS group.

Group Type ACTIVE_COMPARATOR

Enhanced Recovery After Surgery (ERAS) Protocol, which includes early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early urinary catheter removal, an

Intervention Type BEHAVIORAL

The Enhanced Recovery After Surgery (ERAS) Protocol for elective cesarean section includes a multimodal perioperative care approach aimed at accelerating postoperative recovery. Key components are early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early removal of the urinary catheter, and gum chewing to stimulate bowel function. This protocol is compared with Standard Perioperative Cesarean Care, which involves overnight fasting, delayed oral intake until bowel function returns, conventional analgesia, later mobilization, and routine catheter removal.

Interventions

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Enhanced Recovery After Surgery (ERAS) Protocol, which includes early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early urinary catheter removal, an

The Enhanced Recovery After Surgery (ERAS) Protocol for elective cesarean section includes a multimodal perioperative care approach aimed at accelerating postoperative recovery. Key components are early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early removal of the urinary catheter, and gum chewing to stimulate bowel function. This protocol is compared with Standard Perioperative Cesarean Care, which involves overnight fasting, delayed oral intake until bowel function returns, conventional analgesia, later mobilization, and routine catheter removal.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Pregnant women aged 18 years or older

Gestational age ≥37 weeks

Classified as ASA I or ASA II

Scheduled for elective cesarean section under spinal anesthesia

Able and willing to provide informed consent

No chronic systemic diseases

Exclusion Criteria

Age \<18 years

Gestational age \<37 weeks

Emergency cesarean delivery

ASA III or higher

Presence of obstetric complications (e.g., preeclampsia, placenta previa, placental abruption, fetal distress)

Chronic comorbidities (e.g., diabetes, hypertension, cardiac or pulmonary disease)

Declines spinal anesthesia or unable to provide consent
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Havva Betül Bacak

OTHER_GOV

Sponsor Role lead

Responsible Party

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Havva Betül Bacak

M.D

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Bartın City Hospital

Bartın, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Khalafallah AM, Susic N, Shah KH, Knott MV, Berke CN, Gurses ME, Lu VM, Ivan ME, Komotar RJ, Shah AH. Evaluating safety and feasibility of same-day discharge after laser interstitial thermal therapy: a pilot study with a matched control group. J Neurooncol. 2025 Sep;174(2):341-347. doi: 10.1007/s11060-025-05055-4. Epub 2025 May 12.

Reference Type BACKGROUND
PMID: 40355785 (View on PubMed)

Zhang X, Ruan Y, Yuan Y, Li K. Is it necessary to maintain high adherence to enhanced recovery after surgery (ERAS) protocols?-A systematic review and meta-analysis. Curr Probl Surg. 2025 Aug;69:101814. doi: 10.1016/j.cpsurg.2025.101814. Epub 2025 May 30. No abstract available.

Reference Type BACKGROUND
PMID: 40716849 (View on PubMed)

Other Identifiers

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GOEAH-ERAS-CS01

Identifier Type: -

Identifier Source: org_study_id

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