Strength Training Response of Muscle in GLP-1 Users

NCT ID: NCT07104539

Last Updated: 2026-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-08

Study Completion Date

2027-05-31

Brief Summary

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GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.

Detailed Description

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Conditions

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Muscle Mass

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Strenth Training

Participants will undergo strength training 3 times per week for 14 weeks.

Group Type EXPERIMENTAL

Strength Training

Intervention Type BEHAVIORAL

Participants taking a GLP-1 will undergo a 14-week strength training regimen to determine changes in muscle mass. They will perform a series of resistance training exercises supervised by a personal trainer on 3 days per week.

Waitlisted control

Participants will have no strength training intervention for 14 weeks. Participants will be offered the same 14-week strength training program after the initial 14 weeks.

Group Type OTHER

Wait first, then strength training

Intervention Type OTHER

Participants will be waitlisted and receive the 14-week strength training intervention at the end of the waitlist period. During the waitlist period, participants will get no intervention and then be offered the strength training intervention after the first 14 weeks.

Interventions

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Strength Training

Participants taking a GLP-1 will undergo a 14-week strength training regimen to determine changes in muscle mass. They will perform a series of resistance training exercises supervised by a personal trainer on 3 days per week.

Intervention Type BEHAVIORAL

Wait first, then strength training

Participants will be waitlisted and receive the 14-week strength training intervention at the end of the waitlist period. During the waitlist period, participants will get no intervention and then be offered the strength training intervention after the first 14 weeks.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age, 50y+
* Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less
* Weight \<300 lb
* Pass a health and exercise readiness screening

Exclusion Criteria

* Age \<50
* Weight \>300 lb
* Osteoporosis
* Active metabolic, neoplastic, or cardiovascular disease
* Unable or unwilling to provide consent
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Virginia Polytechnic Institute and State University

OTHER

Sponsor Role lead

Responsible Party

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Kevin Davy

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kevin Davy

Role: PRINCIPAL_INVESTIGATOR

Virginia Polytechnic Institute and State University

Locations

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Virginia Tech

Blacksburg, Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Kevin Davy

Role: CONTACT

540-231-3487

Elaina Marinik

Role: CONTACT

540-231-0923

Other Identifiers

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25-707

Identifier Type: -

Identifier Source: org_study_id

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