Parathyroid Adenoma Detection With Rubidium-82 Imaging

NCT ID: NCT07099404

Last Updated: 2025-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-11-30

Study Completion Date

2028-09-30

Brief Summary

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Assess the uptake of rubidium-82 in parathyroid adenomas.

Detailed Description

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Parathyroid adenomas demonstrate uptake of rubidium-82 chloride and can be detected with PET imaging.

The investigators aim to describe the uptake pattern of rubidium-82 chloride in parathyroid adenomas as well as compare the uptake pattern of rubidium-82 chloride to that of 18F-fluorocholine in patients with parathyroid adenoma.

Conditions

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Parathyroid Adenomas Hyperparathyroidism, Primary

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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PET/CT imaging with rubidium-82

PET imaging of the neck will be started immediately before infusion of 10 Megabecquerels per kilograms of rubidum-82 over 30 seconds. The acquisition will last 10 minutes. This will be followed by a non-contrast low-dose CT of the neck for localization and attenuation correction.

Intervention Type OTHER

Other Intervention Names

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Rubidium-82 PET/CT

Eligibility Criteria

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Inclusion Criteria

1. Age ≥ 18y
2. Ability to undergo imaging logistics
3. Ability to provide informed consent
4. Biochemical evidence of primary hyperparathyroidism
5. Documented parathyroid adenoma on prior 18F-fluorocholine imaging

Exclusion Criteria

1. Normocalcemic primary hyperparathyroidism
2. Breastfeeding or pregnancy
3. Claustrophobia or inability to undergo imaging logistics
4. Any other history, condition, therapy, or uncontrolled intercurrent illness, which could in the opinion of the investigator affect compliance with study requirements or which would make the participant unsuitable for this study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Matthieu Pelletier-Galarneau, MD MSc

OTHER

Sponsor Role lead

Responsible Party

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Matthieu Pelletier-Galarneau, MD MSc

Chief of the Nuclear Medicine Department

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Montreal Heart Institute

Montreal, Quebec, Canada

Site Status

Montreal Jewish General Hospital

Montreal, Quebec, Canada

Site Status

Countries

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Canada

Central Contacts

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Matthieu Pelletier-Galarneau, MD MSc

Role: CONTACT

514-376-3330 ext. 4418

Pelletier-Galarneau

Role: CONTACT

Facility Contacts

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Matthieu Pelletier-Galarneau, MD, MSc

Role: primary

514-376-3330 ext. 4418

Gad Abikhzer, MD

Role: primary

514-340-8222

Other Identifiers

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MP-33-2025-3547

Identifier Type: -

Identifier Source: org_study_id

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