Effect of Delivery Method on Umbilical Cord Metabolomic Analysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2025-07-01

Brief Summary

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Birth type is closely linked to fetal and maternal stress responses. In this study, we aimed to examine the effects of delivery method on the stress response in newborns at the metabolite level.

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Detailed Description

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Birth type is closely linked to fetal and maternal stress responses. Previous studies have found higher levels of hormones associated with stress responses in mothers who delivered vaginally compared to those who delivered by cesarean section (C/S). Similarly, differences in markers assessing stress responses in newborns have been observed based on delivery method. However, the literature lacks sufficient studies on low-molecular-weight metabolites, which reveal the metabolic status of newborns.

Metabolomic profiling studies are introductory studies that provide comprehensive information about cell or organism metabolism. They contribute to research in many areas of medicine. In perinatology, metabolomic profiling studies have been conducted on topics such as neural tube defects, intrauterine growth restriction, and maternal diabetes. In this study, we aimed to examine the effects of delivery method on the stress response in newborns at the metabolite level.

Conditions

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Metabolomics Cord Blood

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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C/S

Babies delivered via C/S

No interventions assigned to this group

Vaginal

Babies delivered vaginally

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 1\) Female patient aged 18-35 2) Term pregnancy 3) Pregnant with follow-up

Exclusion Criteria

* 1\) Having been diagnosed with diabetes mellitus before or during pregnancy 2) Having been diagnosed with hypertension before or during pregnancy 3) Non-singleton pregnancy 4) Non-elective C/S 5) Fetal intrauterine growth restriction 6) Mothers and their babies with a fetal birth anomaly or suspected birth anomaly will not be included in this study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No