Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-20

Study Completion Date

2025-10-20

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Dexamethasone Intravenous Versus Intrathecal in Spinal Anesthesia

NCT05470530

Healthy

COMPLETED PHASE1

Dexamethasone for Post-operative Pain After Cesarean Delivery Under Neuraxial Anesthesia.

NCT07257406

Pregnancy Cesarean Delivery Dexamethasone

COMPLETED NA

Bupivacaine Alone vs Bupivacaine and Dexmed in Cesarean Deliveries

NCT05469529

Dexmedetomidine

UNKNOWN NA

Intravenous Dexmedetomidine in Cesarean Section Under Spinal Anesthesia

NCT04358367

Cesarean Section Complications

COMPLETED PHASE3

Effect of Intravenous Dexamethasone Before Spinal Anesthesia on Post-cesarean Section Pain

NCT03122756

Cesarean Section

UNKNOWN EARLY_PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

To prolong the duration of Sub-Arachnoid block number of drugs which are known as adjuvants can be used. One of the commonly used adjuvant is Dexamethasone a steroid given by intravenous route having anti-emetic and anti-inflammatory effect. This drug also prolongs the duration of Sub-Arachnoid block which can be helpful in case of lengthy surgical procedure and also extends the duration of analgesia in the post operative period.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Spinal Anesthesia Post Operative Analgesia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group Dexamethasone

Group Type EXPERIMENTAL

Dexamethasone

Intervention Type DRUG

Immediately after sub-arachnoid block 8mg of Dexamethasone will be administered intravenously

Group Control

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

2ml of Normal saline will be given intravenously immediately after administration of spinal anesthesia

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dexamethasone

Immediately after sub-arachnoid block 8mg of Dexamethasone will be administered intravenously

Intervention Type DRUG

Placebo

2ml of Normal saline will be given intravenously immediately after administration of spinal anesthesia

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* American Society of Anesthesiologists (ASA) class: II and above.
* Elective Cesarean section under Spinal Anesthesia.

Exclusion Criteria

* Gestational diabetes
* Body mass index \>35 kg/m2
* Diabetes mellitus
* Adrenal insufficiency
* Chronically receiving steroids
* Allergic to study medications
* Sensory block level less than T4

Minimum Eligible Age

16 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes