Effect of Vitamin D on Crestal Bone Loss Around Immediate Implant After Mandibular Premolars and Molars Extraction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-20

Study Completion Date

2027-01-01

Brief Summary

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What is the difference between grafting the jumping gap upon using xenograft mixed with topical vitamin D clinically regarding crestal bone level and implant stability, radiographically regarding crestal bone level after implant insertion in the posterior region of mandible?

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Detailed Description

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Effect of Vitamin D on Bone Regeneration .Vitamin D is known for its role in the skeletal system. Vit D deficiency is also widely researched for its effects on the healing of fractures, bone defects and osseointegration of implants. There are studies that investigated the effects of dietary supplementation with vitamin D to reduce vitamin D deficiency but increasing the serum level of this vitamin takes time therefore, an attempt has been made to combat the effect of vitamin D deficiency through topical application. up to the knowledge, upon search of literatures, there is not enough studies that correlate topical application of vitamin D with xenograft mixture as filling space material. this study is to Assess immediate implant with topical vitamin D and xenograft mixture clinically and Radiographically.

Conditions

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Crestal Bone Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

vitamin D solution mixed with xenograft around immediate implant

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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vit D mixed with xenograft

Topical application of vitamin D solution mixed with xenograft in the jumping gap around immediate implant

Group Type ACTIVE_COMPARATOR

vit D mixed with xenograft

Intervention Type DRUG

Topical application of vitamin D solution mixed with xenograft in the jumping gap around immediate implant

only xenograft without vit D

grafting the jumping gap with xenograft only around immediate implant

Group Type PLACEBO_COMPARATOR

only xenograft without vit D

Intervention Type DRUG

grafting the jumping gap with xenograft only around immediate implant

Interventions

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vit D mixed with xenograft

Topical application of vitamin D solution mixed with xenograft in the jumping gap around immediate implant

Intervention Type DRUG

only xenograft without vit D

grafting the jumping gap with xenograft only around immediate implant

Intervention Type DRUG

Other Intervention Names

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cholecalciferol xenotransplant

Eligibility Criteria

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Inclusion Criteria

* The American Society of Anesthesiologist (ASA) I , II
* Both Genders. 3- Patients having unrestorable tooth on the posterior mandibular region
* Age\>20
* The patient who have complete their facial growth and teeth eruption
* No bone disease or lesion in propose implant site

Exclusion Criteria

* Poor oral hygiene patients and/or patients
* Patients with active acute infection.
* Patients with bad oral habits.
* Pregnant or lactating women.
* Heavy smokers.
* Alcohol and drug addicts.
* Diabetes disease

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes