mFOLFOX/mFOLFIRI vs. mFOLFOX in Advanced or Recurrent Biliary Tract Cancer Second-line

NCT ID: NCT07062536

Last Updated: 2025-07-14

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 130 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-08-01
• Study Completion Date: 2028-04-01

Brief Summary

In second line with advanced or recurrent biliary tract cancer refractory to first line gemcitabine plus cisplatin,efficacy of mFOLFOX/FOLFIRI vs mFOLFOX will be evaluated at randomized phase 2 trial.

Detailed Description

1. brief enrollment criteria

• histological confirmed
• refractory to first line gemcitabine plus cisplatin
• fit for chemotherapy

2. treatment arm A. mFOLFOX (Administered as a single regimen every 2weeks) 1) mFOLFOX D1 Oxaliplatin 85mg/m2 over 2hr Leucovorin 400mg/m2 over 2hr Fluorouracil 400mg/m2 FU 2400mg/m2 over 46hr

treatment arm B. mFOLFOX/mFOLFIRI (Administered alternately every 2 weeks.) 1) mFOLFOX D1 Oxaliplatin 85mg/m2 over 2hr Leucovorin 400mg/m2 over 2hr Fluorouracil 400mg/m2 FU 2400mg/m2 over 46hr 2) mFOLFIRI D1 Irinotecan 150mg/m2 over 2hr Leucovorin 100mg/m2 over 2hr 5FU 2400mg/m2 over 46hr

3. randomization - stratified by site and performance status

• Previous cancer treatment (including IO agents vs. excluding IO agents)

Conditions

Biliary Cancer Metastatic

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

mFOLFOX

1\) mFOLFOX (Administered as a single regimen every 2weeks) D1 Oxaliplatin 85mg/m2 over 2hr Leucovorin 400mg/m2 over 2hr Fluorouracil 400mg/m2 FU 2400mg/m2 over 46hr

Group Type: EXPERIMENTAL

Oxaliplatin, 5FU, leucovorin

Intervention Type: DRUG

Administered as a single regimen every 2weeks

mFOLFOX/mFOLFIRI

(Administered alternately every 2 weeks.)

1. mFOLFOX D1 Oxaliplatin 85mg/m2 over 2hr Leucovorin 400mg/m2 over 2hr Fluorouracil 400mg/m2 FU 2400mg/m2 over 46hr

2. mFOLFIRI D1 Irinotecan 150mg/m2 over 2hr Leucovorin 100mg/m2 over 2hr 5FU 2400mg/m2 over 46hr

Group Type: EXPERIMENTAL

Oxaliplatin, 5FU, leucovorin/Irinotecan , 5FU, leucovorin,

Intervention Type: DRUG

Administered alternately every 2weeks

Interventions

Oxaliplatin, 5FU, leucovorin

Administered as a single regimen every 2weeks

Intervention Type: DRUG

Oxaliplatin, 5FU, leucovorin/Irinotecan , 5FU, leucovorin,

Administered alternately every 2weeks

Intervention Type: DRUG

Other Intervention Names

mFOLFOX; mFOLFOX/mFOLFIRI

Eligibility Criteria

Inclusion Criteria

1. Age ≥ 19 years.

2. Diagnosed with biliary tract cancer, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, or ampulla of Vater cancer.

3. Either unresectable advanced disease or recurrence after curative surgery.

4. ECOG (Eastern Cooperative Oncology Group) performance status of 0-2

5. First-Line Treatment Failure: Disease progression after at least one cycle of gemcitabine/cisplatin-based therapy or discontinuation of therapy due to adverse effects.

6. Presence of evaluable or measurable lesions according to RECIST v1.1 criteria.

7. Laboratory Criteria: optima bone marrow, liver, and kidney function within one week prior to enrollment: A. Hemoglobin > 9.0 g/dL B. Absolute neutrophil count (ANC) > 1,000/uL C. Platelet count > 75,000/uL D. Serum creatinine < 1.5× upper limit of normal (ULN) E. AST/ALT < 3× ULN F. Total bilirubin < 1.5× ULN (biliary drainage is allowed).

8. Patients who understand the study protocol, can provide written informed consent, and are aware of their right to withdraw at any time without penalty.

9. Effective Contraception (for patients of childbearing potential receiving oxaliplatin):

A. Male patients:

Must use effective contraception during the study and for 12 months after treatment completion.

B. Female patients:

Must use effective contraception during the study and for 15 months after treatment completion.

Exclusion Criteria

1. Patients with prior exposure to oxaliplatin or irinotecan in previous cancer treatments.

2. Patients with metastatic or unresectable biliary tract cancer who have received second- line or higher chemotherapy.

3. Pregnant or breastfeeding women.

4. Patients with a history of other malignancies within the past 3 years, except for papillary or follicular thyroid cancer.

5. Patients with uncontrolled infections or other systemic diseases.

6. Patients with a history of myocardial infarction, unstable angina, or heart failure (NYHA

7. Class III-IV) within the last 6 months.

8. Patients with Grade 3 or higher peripheral neuropathy caused by prior chemotherapy.

9. Patients with known allergic reactions to the investigational drugs.

10. Known patients with Gilbert's syndrome, DPD (dihydro-pyrimidine dehydrogenase) deficiency, or Homozygous UGT1A1*28 alleles.

11. Patients currently taking potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin), or potent CYP3A4 inducers (e.g., rifampin, carbamazepine, St.

John's Wort).

12. Patients who are eligible for targeted therapy, including FGFR inhibitors or IDH1 inhibitors. (eligible for patient who unable to use these targeted agents due to drug cost.)

13. Patients with active CNS metastases and/or carcinomatous meningitis.

14. Patients who meet contraindications for the investigational drugs as per domestic regulatory guidelines, including patients with infections, Interstitial pneumonitis or pulmonary fibrosis, Severe diarrhea, Chronic inflammatory bowel disease, Intestinal paralysis or obstruction, Functional impairment due to peripheral sensory neuropathy, Severe renal dysfunction.

15. Patients deemed ineligible by the investigator for any other reason.

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Seoul National University Bundang Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jin Won Kim

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sun A Han

Role: STUDY_DIRECTOR

Seoul National University Bundang Hospital

Locations

Jin Won Kim

Seongnam-si, Out of US, South Korea

Countries

South Korea

Central Contacts

Jin Won MD Kim, PhD

Role: CONTACT

jwkim@snubh.org

82-31-787-7053

Provided Documents

Document Type: Study Protocol

View Document

Other Identifiers

Art-BTC

Identifier Type: -

Identifier Source: org_study_id