Illness Perception and Quality of Life in Colorectal Cancer With Ascites

NCT ID: NCT07059052

Last Updated: 2025-07-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 218 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2025-04-30

Brief Summary

This study aimed to investigate the impact of illness perception on the quality of life (QoL) in patients diagnosed with colorectal cancer (CRC) complicated by ascites. The study explores how patients' cognitive and emotional beliefs about their illness relate to their physical, psychological, and social well-being.

Detailed Description

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, and many patients are diagnosed at advanced stages with complications such as malignant ascites, which severely impairs quality of life (QoL). Illness perception, the framework of beliefs a patient develops about their illness, is known to influence health outcomes. However, this relationship is not well-studied in the specific subgroup of CRC patients with ascites.

This cross-sectional, observational study was designed to fill this gap. A total of 218 patients with CRC and ascites were enrolled. The study collected clinical and demographic data, and assessed illness perception using the Brief Illness Perception Questionnaire (BIPQ) and QoL using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). The primary goal was to analyze the correlation between dimensions of illness perception and domains of QoL, and to identify independent clinical and demographic factors that predict patient QoL. The findings are intended to inform the development of targeted psychosocial interventions to improve patient well-being in this vulnerable population.

Conditions

Colorectal Cancer (MSI-H)

Study Design

• Observational Model Type: CASE_CROSSOVER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Patients with Colorectal Cancer and Ascites

A single cohort of 218 patients with a confirmed diagnosis of colorectal cancer and concomitant ascites. These patients were treated at the Hebei Provincial Hospital of Traditional Chinese Medicine between January 2024 and April 2025. Data on their clinical characteristics, illness perceptions, and quality of life were collected at a single point in time for this cross-sectional analysis.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Confirmed diagnosis of colorectal cancer with ascites, verified by imaging and pathological examination.
• Patient and/or legal guardian provided informed consent.
• Karnofsky Performance Status (KPS) score ≥50.
• Estimated survival ≥6 months.

Exclusion Criteria

• Presence of other active malignant tumors.
• Severe physical disability precluding participation.
• Severe cardiac, hepatic, or renal dysfunction not related to CRC.
• Presence of severe psychiatric or cognitive disorders.
• History of alcohol or drug addiction.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hebei Provincial Hospital of Traditional Chinese Medicine

OTHER_GOV

Sponsor Role: lead

Responsible Party

Xujin Guo

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hebei Provincial Hospital of Traditional Chinese Medicine

Shijiazhuang, Hebei, China

Countries

China

Other Identifiers

2024021

Identifier Type: -

Identifier Source: org_study_id