Ultrasound Duration Effects on Knee Osteoarthritis Pain and Function

NCT ID: NCT07057869

Last Updated: 2025-07-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-01

Study Completion Date

2025-06-30

Brief Summary

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This study aims to compare the effects of different ultrasound treatment durations on pain and physical function in patients with knee osteoarthritis. Sixty sedentary volunteers aged 18-85 with diagnosed knee osteoarthritis will be randomly assigned to three groups receiving ultrasound therapy for 5, 10, or 15 minutes, respectively, alongside conventional treatment. Pain and physical function will be assessed using the Visual Analog Scale (VAS), WOMAC Osteoarthritis Index, and 2-minute walk test at baseline and after 4 weeks of treatment. The results will help determine the optimal ultrasound treatment duration for improving symptoms in knee osteoarthritis patients.

Detailed Description

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This clinical trial investigates the effects of different ultrasound therapy durations on pain relief and physical function improvement in patients with knee osteoarthritis. Sixty sedentary individuals aged 18 to 85 years diagnosed with knee osteoarthritis will be enrolled and randomly assigned to three groups receiving ultrasound treatment for 5, 10, or 15 minutes, respectively, alongside conventional therapy (such as hot packs, TENS, etc.).

Ultrasound therapy will be applied by a qualified physiotherapist at 1 W/cm² intensity and 1 MHz frequency in pulsed mode, for four weeks. Evaluations will be conducted at baseline and after treatment completion, using the Visual Analog Scale (VAS) for pain assessment, WOMAC Osteoarthritis Index for physical function, and a 2-minute walk test to measure walking performance.

This study aims to provide scientific evidence on the optimal ultrasound treatment duration for knee osteoarthritis, contributing to improved rehabilitation protocols. The findings will be prepared for publication in an international peer-reviewed journal.

Conditions

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Knee Osteoarthristis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This is a randomized controlled trial where 60 patients with knee osteoarthritis are randomly assigned to three groups receiving ultrasound therapy for 5, 10, or 15 minutes respectively. All groups receive conventional treatment alongside ultrasound therapy. The effects on pain and physical function are evaluated before and after a 4-week treatment period.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

This study is an open-label trial where both patients and treating physiotherapists are aware of the ultrasound treatment duration. Outcome assessors are blinded to group assignments to reduce assessment bias.

Study Groups

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5-minute Ultrasound Group

Patients receive 5 minutes of pulsed ultrasound therapy (1 W/cm², 1 MHz) alongside conventional treatment for 4 weeks.

Group Type EXPERIMENTAL

5-minute Ultrasound Group

Intervention Type PROCEDURE

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 5 minutes per session, 4 weeks duration.

10-minute Ultrasound Group

Patients receive 10 minutes of pulsed ultrasound therapy (1 W/cm², 1 MHz) alongside conventional treatment for 4 weeks.

Group Type EXPERIMENTAL

10-minute Ultrasound Group

Intervention Type PROCEDURE

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 10 minutes per session, 4 weeks duration.

15-minute Ultrasound Group

Patients receive 15 minutes of pulsed ultrasound therapy (1 W/cm², 1 MHz) alongside conventional treatment for 4 weeks.

Group Type EXPERIMENTAL

15-minute Ultrasound Group

Intervention Type PROCEDURE

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 15 minutes per session, 4 weeks duration.

Interventions

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5-minute Ultrasound Group

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 5 minutes per session, 4 weeks duration.

Intervention Type PROCEDURE

10-minute Ultrasound Group

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 10 minutes per session, 4 weeks duration.

Intervention Type PROCEDURE

15-minute Ultrasound Group

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 15 minutes per session, 4 weeks duration.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Individuals aged between 18 and 85 years Diagnosed with knee osteoarthritis Recommended for ultrasound therapy as part of routine physical therapy Willing to participate voluntarily and provide written informed consent

Exclusion Criteria

History of acute knee trauma Individuals with contraindications to ultrasound therapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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KTO Karatay University

OTHER

Sponsor Role lead

Responsible Party

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Mustafa Savaş Torlak

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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KTO Karatay Üniversitesi

Konya, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Eyigor S, Karapolat H, Ibisoglu U, Durmaz B. [Does transcutaneous electrical nerve stimulation or therapeutic ultrasound increase the effectiveness of exercise for knee osteoarthritis: a randomized controlled study]. Agri. 2008 Jan;20(1):32-40. Turkish.

Reference Type RESULT
PMID: 18338277 (View on PubMed)

Paget C, Chow MT, Duret H, Mattarollo SR, Smyth MJ. Role of gammadelta T cells in alpha-galactosylceramide-mediated immunity. J Immunol. 2012 Apr 15;188(8):3928-39. doi: 10.4049/jimmunol.1103582. Epub 2012 Mar 12.

Reference Type RESULT
PMID: 22412194 (View on PubMed)

Rutjes AW, Nuesch E, Sterchi R, Juni P. Therapeutic ultrasound for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD003132. doi: 10.1002/14651858.CD003132.pub2.

Reference Type RESULT
PMID: 20091539 (View on PubMed)

Huang MH, Lin YS, Lee CL, Yang RC. Use of ultrasound to increase effectiveness of isokinetic exercise for knee osteoarthritis. Arch Phys Med Rehabil. 2005 Aug;86(8):1545-51. doi: 10.1016/j.apmr.2005.02.007.

Reference Type RESULT
PMID: 16084806 (View on PubMed)

Cetin N, Aytar A, Atalay A, Akman MN. Comparing hot pack, short-wave diathermy, ultrasound, and TENS on isokinetic strength, pain, and functional status of women with osteoarthritic knees: a single-blind, randomized, controlled trial. Am J Phys Med Rehabil. 2008 Jun;87(6):443-51. doi: 10.1097/PHM.0b013e318174e467.

Reference Type RESULT
PMID: 18496246 (View on PubMed)

Other Identifiers

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KaratayMST-2

Identifier Type: -

Identifier Source: org_study_id

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