Comparison of Pruritus Incidence After Intrathecal Morphine 0.1 vs 0.2 mg in Cesarean Section
NCT ID: NCT07054775
Last Updated: 2025-07-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
69 participants
INTERVENTIONAL
2025-06-01
2025-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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ITM 0.1 mg
Participants receive spinal anesthesia with 0.5% hyperbaric bupivacaine plus morphine 0.1 mg intrathecally
Morphine Sulfate
intrathecal administered morphine
ITM 0.2 mg
Participants receive spinal anesthesia with 0.5% hyperbaric bupivacaine plus morphine 0.2 mg intrathecally
Morphine Sulfate
intrathecal administered morphine
Interventions
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Morphine Sulfate
intrathecal administered morphine
Eligibility Criteria
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Inclusion Criteria
* Scheduled for non-emergency cesarean section
* ASA physical status I-III
* Non-complicated pregnancy
Exclusion Criteria
* Refusal to participate in the study
* BMI ≥ 40 kg/m²
* History of systemic skin disease or current itchy skin condition
* Use of antihistamines or anti-pruritic medications within 3 days prior to surgery
18 Years
45 Years
FEMALE
Yes
Sponsors
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Khon Kaen University
OTHER
Responsible Party
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Thepakorn Sathitkarnmanee
Associate professor
Principal Investigators
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Thepakorn Sathitkarnmanee
Role: STUDY_CHAIR
Faculty of Medicine, Khon Kaen University
Locations
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Faculty of Medicine, Khon Kaen University
Khon Kaen, , Thailand
Thepakorn Sathitkarnmanee
Khon Kaen, , Thailand
Countries
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Central Contacts
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Facility Contacts
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References
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Kumar K, Singh SI. Neuraxial opioid-induced pruritus: An update. J Anaesthesiol Clin Pharmacol. 2013 Jul;29(3):303-7. doi: 10.4103/0970-9185.117045.
Waxler B, Dadabhoy ZP, Stojiljkovic L, Rabito SF. Primer of postoperative pruritus for anesthesiologists. Anesthesiology. 2005 Jul;103(1):168-78. doi: 10.1097/00000542-200507000-00025.
Sultan P, Halpern SH, Pushpanathan E, Patel S, Carvalho B. The Effect of Intrathecal Morphine Dose on Outcomes After Elective Cesarean Delivery: A Meta-Analysis. Anesth Analg. 2016 Jul;123(1):154-64. doi: 10.1213/ANE.0000000000001255.
Gehling M, Tryba M. Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis. Anaesthesia. 2009 Jun;64(6):643-51. doi: 10.1111/j.1365-2044.2008.05817.x.
Palmer CM, Emerson S, Volgoropolous D, Alves D. Dose-response relationship of intrathecal morphine for postcesarean analgesia. Anesthesiology. 1999 Feb;90(2):437-44. doi: 10.1097/00000542-199902000-00018.
Wang W, Zhou L, Sun L. Ondansetron for neuraxial morphine-induced pruritus: A meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2017 Aug;42(4):383-393. doi: 10.1111/jcpt.12539. Epub 2017 May 2.
Other Identifiers
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HE631484
Identifier Type: -
Identifier Source: org_study_id
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