Improving Menstrual Health Through BCC Among Bangladeshi University Students
NCT ID: NCT07047222
Last Updated: 2025-07-02
Study Results
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Basic Information
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COMPLETED
NA
498 participants
INTERVENTIONAL
2023-05-20
2024-03-31
Brief Summary
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Three structured educational sessions on menstrual health, healthy diet, and physical activity were delivered by trained female educators between May 20 and June 30, 2023, at Patuakhali Science and Technology University, Barishal University, and Khulna University. Participation was voluntary. Reinforcement follow-ups were conducted every two months for six months.
A quasi-experimental design was employed. Post-intervention data were collected from February to March 2024. Based on sample size calculations assuming a 30% reduction in disorder prevalence, 498 students (249 per group) were initially enrolled. After exclusions, 234 intervention and 238 control participants were analyzed for dysmenorrhea; 228 per group for PMS and MI. Propensity score matching (1:1, caliper 0.01, no replacement) yielded 98 matched participants per group for final analysis.
Eligible participants were female students aged ≥19 years, residing in university dormitories. Data collection used validated Bengali-language, interviewer-administered questionnaires, based on relevant literature and menstrual health IEC materials. Trained female enumerators ensured data quality and participant comfort.
Primary outcomes were: (1) Dysmenorrhea, measured by the Andersch and Milsom score (dichotomized Yes/No); (2) PMS, assessed using the Premenstrual Symptoms Screening Tool, with no/mild PMS and moderate to severe PMS/PMDD as the outcome; (3) MI, defined as self-reported menstrual cycles \<21 or \>35 days. The treatment variable was BCC exposure (Yes/No).
Covariates included physical activity, BMI, dietary diversity (DDS ≥5), food cravings, breakfast skipping, sleep duration, caffeine use, bedtime, family history of menstrual disorders, age at menarche, marital status, residence, and parental education and occupation.
Baseline differences were assessed using descriptive statistics, chi-square, and t-tests. Conditional logistic regression estimated intervention effects on matched data. Sensitivity analyses (ATE, ATT, balance diagnostics, Bayesian logistic regression) supported the robustness of results.
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Detailed Description
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The study employed a quasi-experimental design involved two groups: an intervention group that received BCC module and a control group that did not. Participants were female undergraduate students at three public universities in Bangladesh i.e. Patuakhali Science and Technology University (PSTU), Barishal University (BU), and Khulna University (KU). Ethical approval was obtained from the Shahjalal University of Science and Technology Research Ethics Board (Ref. No. AST/002/258), and all participants provided written informed consent.
The BCC intervention comprised three interactive educational sessions delivered between May 20 and June 30, 2023, by trained female facilitators. The first session addressed menstrual disorders and associated risk factors, the second focused on healthy dietary practices, and the third emphasized physical activity (including yoga) and other relevant lifestyle modifications. To enhance retention and adherence, follow-up visits were conducted bi-monthly for six months after the intervention to reinforce key messages and address participant questions or barriers to behavior change. Post-intervention data collection was carried out between February and March 2024.
Participants were eligible if they were female students aged 19 years or older, residing full-time in university dormitories, and not currently taking hormonal treatments or diagnosed with chronic illnesses affecting menstruation. Recruitment occurred through record book of student dormitories at each university and student networks. Informed written consent was obtained prior to participation.
Data were collected through interviewer-administered questionnaires, adapted and validated in Bengali for cultural relevance and comprehension. Instruments were based on existing literature and government-endorsed information, education, and communication (IEC) materials on menstrual health. All interviews were conducted by trained female enumerators to ensure a comfortable and respectful environment for participants.
The sample size was calculated to detect a 30% reduction in the prevalence of menstrual disorders, with 80% statistical power and a 95% confidence interval, accounting for an anticipated dropout rate. Initially, 498 participants were recruited-249 each in the intervention and control groups. After excluding individuals with missing follow-up data or incomplete attendance, 234 participants in the intervention group and 238 in the control group were included in the analysis for dysmenorrhea. For PMS and MI outcomes, 228 participants per group had valid data.To control for potential confounding, 1:1 propensity score matching (PSM) was conducted using nearest-neighbor matching with a caliper of 0.01 and without replacement. Matching was based on baseline characteristics to ensure statistical equivalence between groups. After matching, a balanced analytical sample of 196 participants (98 in each group) was retained for all outcome analyses.
Among all the primary outcomes, dysmenorrhea was assessed using the Andersch and Milsom four-point scale and dichotomized as no pain (Grade 0) vs. any pain (Grades 1 - 3). PMS was evaluated by the premenstrual symptoms screening tool (PSST) and recoded into a binary variable: No/Mild PMS (code = 0) and Moderate to Severe PMS or premenstrual dysphoric disorder (PMDD) (code = 1). Additionally, Menstrual irregularity was determined based on self-reported cycle length and coded as irregular (1) if \<21 or \>35 days, and not irregular (0) if within the 21-35 day range.
The primary exposure variable was participation in the BCC intervention, coded as yes (intervention group) or no (control group).
The covariates included physical activity, obesity, dietary habits, lifestyle factors, and socio-demographic characteristics. Physical activity was classified according to WHO guidelines as: (i) sedentary: light-intensity activities; (ii) active: moderate-intensity activities for 150-300 minutes per week; and (iii) athlete: vigorous-intensity activities for 75-150 minutes per week. Obesity was assessed using body mass index (BMI, kg/m²) and categorized according to WHO Asian-specific cut-offs: (i) underweight (\<18.5), (ii) normal weight (18.5-22.9), (iii) overweight (23.0-27.5), and (iv) obese (\>27.5). Dietary information was evaluated through 24-hour dietary recall using FAO's Minimum Dietary Diversity for Women (MDD-W) scoring system, with scores ≥5 indicating adequate diversity was collected using a five-day 24-hour recall method, and dietary diversity score (DDS) was calculated following FAO guidelines. Lifestyle-related covariates included food cravings for high-fat or sweet foods, skipping breakfast, sleep duration, bedtime and caffeine intake. Socio-demographic variables included family history of menstrual disorders, age at menarche, marital status, and participants' residence as well as parental educational and occupational status.
Data analysis was performed using Stata 17. The following steps were undertaken:
1. Descriptive statistics summarized baseline demographic and behavioral characteristics. Chi-square (χ²) tests were used for categorical variables, and independent-sample t-tests for continuous variables.
2. Propensity score matching (PSM) was conducted using logistic regression to estimate the probability of receiving the intervention, based on the identified covariates. Nearest-neighbor matching (1:1) with a caliper width of 0.01 (no replacement) was applied. Balance between groups post-matching was assessed using standardized mean differences (SMD), with values \<10% indicating adequate balance.
3. Primary analyses of intervention effects were conducted using conditional logistic regression on the matched sample to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each outcome.
4. To confirm the robustness of the findings, bivariate and multivariate logistic regression analyses were also performed on the unmatched sample, adjusting for covariates.
5. Sensitivity analyses were carried out to assess the stability of the results, including: covariate balance diagnostics (before and after matching); estimation of Average Treatment Effect (ATE) and Average Treatment Effect on the Treated (ATT); Bayesian logistic regression, including log Bayes factor interpretation, to evaluate model fit and strength of evidence for intervention effects. However, All statistical tests were two-sided, with a significance level set at p \< 0.05.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Intervention group
Female university students who voluntarily registered for the structured BCC module formed the intervention group. The module comprised three interactive sessions that combined educational presentations, yoga demonstrations, distribution of informative pamphlets, quiz-based learning, and the provision of small rewards to encourage active engagement. To support lasting behavior change and address any ongoing challenges, follow-up sessions were conducted every two months.
Behavioral change communication (BCC) module
The behavior change communication (BCC) module was designed to enhance awareness and promote effective management of menstrual disorders through structured lifestyle and behavioral guidance. It consisted of three 1-hour sessions: (1) education on menstrual disorders and related risk factors; (2) healthy dietary practices; and (3) physical activity (including yoga) and other lifestyle improvements. Sessions were held from May 20 to June 30, 2023, at three public universities in Bangladesh and were delivered by trained female educators. All session dates were approved by university authorities. Activities included interactive presentations, yoga demonstrations, pamphlet distribution, quizzes, and gift giveaways. To reinforce and support behavior change, follow-up visits were conducted every two months from July 15, 2023, to January 15, 2024.
Control group
The Control group consisted of female students from the same universities who did not receive any educational session of BCC module or follow-up during the intervention period. They were selected using student dormitory records and matched to the intervention group through propensity score matching to ensure comparability. As they did not receive any form of intervention, this group served as the matched comparison group for evaluating the effectiveness of the BCC module on menstrual health outcomes.
No interventions assigned to this group
Interventions
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Behavioral change communication (BCC) module
The behavior change communication (BCC) module was designed to enhance awareness and promote effective management of menstrual disorders through structured lifestyle and behavioral guidance. It consisted of three 1-hour sessions: (1) education on menstrual disorders and related risk factors; (2) healthy dietary practices; and (3) physical activity (including yoga) and other lifestyle improvements. Sessions were held from May 20 to June 30, 2023, at three public universities in Bangladesh and were delivered by trained female educators. All session dates were approved by university authorities. Activities included interactive presentations, yoga demonstrations, pamphlet distribution, quizzes, and gift giveaways. To reinforce and support behavior change, follow-up visits were conducted every two months from July 15, 2023, to January 15, 2024.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Currently enrolled as full-time undergraduate students at one of the following selected public universities in Bangladesh: Patuakhali Science and Technology University (PSTU), Barisal University (BU), or Khulna University (KU). These institutions were selected based on logistical feasibility and representativeness of the target population.
* Willing and able to provide written informed consent after being fully informed of the study's purpose, procedures, potential risks, and benefits, and their rights as participants. Informed consent was obtained in accordance with ethical guidelines of SUST Research Ethics Board (SREB).
* Available and committed to participating in all phases of the study, including all three intervention sessions (BCC module), bimonthly follow-up over a six-month period (July 2023 to January 2024) and in evaluation of the intervention's effectiveness.
* Have regular access to a mobile phone, email, or another reliable means of communication to receive reminders, updates, and follow-up contacts related to intervention sessions and data collection.
* Able to comprehend and respond to study instructions and questionnaires in either Bengali or English, ensuring accurate data collection and meaningful engagement in the intervention.
* Not currently pregnant or breastfeeding, as confirmed during initial screening, to ensure hormonal stability and comparability across participants.
Exclusion Criteria
* History of major abdominal or gynecological surgery (e.g., hysterectomy, oophorectomy, or myomectomy) that may affect menstrual function or reproductive physiology.
* Clinical diagnosis of chronic gynecological conditions, including but not limited to polycystic ovary syndrome (PCOS), endometriosis, or uterine fibroids.
* Diagnosed with chronic endocrine disorders such as thyroid disease, adrenal disorders, or diabetes mellitus, which may affect menstrual health.
* Pregnant, planning to conceive, or currently breastfeeding at the time of enrollment.
* Participation in another clinical trial or intervention study related to reproductive health, dietary habit, or physical activity.
* Presence of any diagnosed psychiatric illness or cognitive impairment that could interfere with participation in educational sessions or accurate reporting of menstrual symptoms.
* Refusal or inability to provide informed consent or commit to the follow-up schedule.
19 Years
25 Years
FEMALE
Yes
Sponsors
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Shahjalal University of Science and Technology
OTHER
Responsible Party
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G.M. Rabiul Islam
principal investigator (PI) of the study
Principal Investigators
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GM Rabiul Islam, PhD
Role: PRINCIPAL_INVESTIGATOR
Shahjalal University of Science and Technology Research
Locations
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Patuakhali Science and technology University
Dumki, Patuakhali, Bangladesh
Countries
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References
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Mitsuhashi R, Sawai A, Kiyohara K, Shiraki H, Nakata Y. Factors Associated with the Prevalence and Severity of Menstrual-Related Symptoms: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Dec 29;20(1):569. doi: 10.3390/ijerph20010569.
Hanley-Cook GT, Tung JYA, Sattamini IF, Marinda PA, Thong K, Zerfu D, Kolsteren PW, Tuazon MAG, Lachat CK. Minimum Dietary Diversity for Women of Reproductive Age (MDD-W) Data Collection: Validity of the List-Based and Open Recall Methods as Compared to Weighed Food Record. Nutrients. 2020 Jul 9;12(7):2039. doi: 10.3390/nu12072039.
WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004 Jan 10;363(9403):157-63. doi: 10.1016/S0140-6736(03)15268-3.
Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, Carty C, Chaput JP, Chastin S, Chou R, Dempsey PC, DiPietro L, Ekelund U, Firth J, Friedenreich CM, Garcia L, Gichu M, Jago R, Katzmarzyk PT, Lambert E, Leitzmann M, Milton K, Ortega FB, Ranasinghe C, Stamatakis E, Tiedemann A, Troiano RP, van der Ploeg HP, Wari V, Willumsen JF. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020 Dec;54(24):1451-1462. doi: 10.1136/bjsports-2020-102955.
Ansong E, Arhin SK, Cai Y, Xu X, Wu X. Menstrual characteristics, disorders and associated risk factors among female international students in Zhejiang Province, China: a cross-sectional survey. BMC Womens Health. 2019 Feb 18;19(1):35. doi: 10.1186/s12905-019-0730-5.
Steiner M, Macdougall M, Brown E. The premenstrual symptoms screening tool (PSST) for clinicians. Arch Womens Ment Health. 2003 Aug;6(3):203-9. doi: 10.1007/s00737-003-0018-4.
Andersch B, Milsom I. An epidemiologic study of young women with dysmenorrhea. Am J Obstet Gynecol. 1982 Nov 15;144(6):655-60. doi: 10.1016/0002-9378(82)90433-1.
Sen LC, Jahan I, Salekin N, Shourove JH, Rahman M, Uddin MJ, Zhang C, H Hamer D, Islam GMR. Food craving, vitamin A, and menstrual disorders: A comprehensive study on university female students. PLoS One. 2024 Sep 25;19(9):e0310995. doi: 10.1371/journal.pone.0310995. eCollection 2024.
Slap GB. Menstrual disorders in adolescence. Best Pract Res Clin Obstet Gynaecol. 2003 Feb;17(1):75-92. doi: 10.1053/ybeog.2002.0342.
Rupe ER, Rodean J, Hurley EA, Miller MK, Boncoeur MD, Masonbrink AR. Menstrual health among adolescents and young adults in rural Haiti. Reprod Health. 2022 Dec 20;19(1):227. doi: 10.1186/s12978-022-01533-4.
Provided Documents
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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form
Other Identifiers
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AST/002/258
Identifier Type: -
Identifier Source: org_study_id
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