Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid

NCT ID: NCT07046208

Last Updated: 2025-07-01

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 58 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-08-11
• Study Completion Date: 2026-09-30

Brief Summary

Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.

Conditions

Long COVID; Heart Rate Variability (HRV); Cardiac Biomarkers; Inflammatory Biomarkers

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

Rehabilitation for long covid

Physioterapy protocol

Group Type: EXPERIMENTAL

physiothreapy protocol

Intervention Type: OTHER

Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).

Interventions

physiothreapy protocol

Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• both sexes
• aged 20 and 59 years
• clinical evaluation and undergoing clinical follow-up of Post COVID-19.
• least one persistent COVID-19-related symptom.

Exclusion Criteria

• incomplete data.
• presence of a pacemaker
• use of antihypertensive drugs that alter HRV
• persistent pulmonary alterations
• persistent desaturation
• anaemia or presence of reinfection.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 59 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Universidade do Estado do Pará

OTHER

Sponsor Role: lead

Responsible Party

Luiz Fábio Magno Falcão, PhD

Researcher

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Luiz Magno Falcão, Research and coordinator

Role: CONTACT

fabiofalcao@uepa.br

+5591982379488

References

Marques KC, Silva CC, Trindade SDS, Santos MCS, Rocha RSB, Vasconcelos PFDC, Quaresma JAS, Falcao LFM. Reduction of Cardiac Autonomic Modulation and Increased Sympathetic Activity by Heart Rate Variability in Patients With Long COVID. Front Cardiovasc Med. 2022 Apr 29;9:862001. doi: 10.3389/fcvm.2022.862001. eCollection 2022.

Reference Type: RESULT

PMID: 35571200 (View on PubMed)

Provided Documents

Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Other Identifiers

4252664

Identifier Type: REGISTRY

Identifier Source: secondary_id

36459920400005174

Identifier Type: -

Identifier Source: org_study_id