Eccentric Cycling Exercise During Pulmonary Rehabilitation in Patients With Cardiopulmonary Diseases

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-02

Study Completion Date

2026-05-30

Brief Summary

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Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease. Furthermore, we conducted an RCT in which we exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle. The study in patients with PVD was started (EccRehab), and the great potential was recognized. Therefore there was an indication to open the inclusion criteria to all cardiopulmonary patients with indication for pulmonary rehabilitation (EccRehab2).

For this purpose, the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with cardiopulmonary diseases.

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Detailed Description

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Conditions

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Eccentric Exercise Training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Intervention: Eccentric cycling (instead of usual cycling) + standard care Control: Standard care

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Eccentric cycling

Patients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation

Group Type EXPERIMENTAL

Eccentric cycling exercise

Intervention Type OTHER

Patients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation

Standard care

Patients perform cardiopulmonary rehabilitation according to standard care

Group Type ACTIVE_COMPARATOR

Standard Care Arm

Intervention Type OTHER

Patients perform cardiopulmonary rehabilitation according to standard care

Interventions

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Eccentric cycling exercise

Patients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation

Intervention Type OTHER

Standard Care Arm

Patients perform cardiopulmonary rehabilitation according to standard care

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with PVD, either PAH or CTEPH via right heart catheterization, according to recent guidelines \[9\]
* Diagnosed with a cardiopulmonary disease as indication for a pulmonary rehabilitation
* Stable medication for at least 1 month
* Age 18years to 85 years
* No resting hypoxemia (PaO2 \>7.3 kPa)
* Medical indication to prescibe a pulmonary rehabilitation

Exclusion Criteria

* Any co-morbidity that limits the patient to participate the full rehabilitation
* Enrollments in other trials with active treatments
* Language barriers that limits the patient to participate in the rehabilitation

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No