Stress Trajectories and Anhedonia in Adolescence Research Study
NCT ID: NCT07040449
Last Updated: 2025-06-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
192 participants
INTERVENTIONAL
2025-03-12
2030-02-28
Brief Summary
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The main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time.
This study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete surveys, provide samples of spit to measure hormones and provide pictures of their brain to measure brain activity, participate in mildly stressful tasks, and complete different activities that measure how they think. The investigators will also ask each adolescent's parent or legal guardian to answer some surveys about themselves and their child.
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Detailed Description
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The assessments being administered at all three timepoints are:
* Psychological measures (self-report, completed remotely): Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), Mood and Feelings Questionnaire short version (MFQ), Patient-Reported Outcomes Measurement Information System (PROMIS) Emotional Distress and Anxiety, PROMIS Psychological Stress Experiences, Snaith-Hamilton Pleasure Scale (SHAPS), Temporal Experience of Pleasure Scale (TEPS)
* Cognitive (researcher administered, conducted in-person): NIH Cognitive Toolbox
* Brain Imaging via functional magnetic resonance imaging (fMRI)
* Physiological (researcher administered, conducted in-person): Heart Rate Variability (HRV), Photoplethysmography (PPG), Impedance Cardiography (ICG), Pre-Ejection Period (PEP), Salivary Cortisol
Additionally, the following will be administered at each respective timepoint:
Baseline Assessment (Month 0):
Self-Report, Remote Questionnaires: demographic survey, address history survey, Protocol for Responding to \& Assessing Patients' Assets, Risks \& Experiences (PRAPARE), Pediatric Adverse Childhood Experiences and Related Life-events Screener (PEARLS) Cognitive (researcher administered, conducted in-person: Wechsler Abbreviated Scale of Intelligence Second Version (WASI-II) Psychological interview: Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS)
Time 2 (10-Months) Juvenile Victimization Questionnaire (JVQ) (self-report, completed remotely)
Time 3 (20-Months) Psychological interview: Abbreviated Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS)
Conditions
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Study Design
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NA
SINGLE_GROUP
2. The Montreal Imaging Stress Task (MIST) -- Psychosocial stress procedure consisting of completing sections of mental arithmetic that are 5.5 minutes in length, during which the individual receives neutral and negative evaluative feedback about their performance relative to their peers.
BASIC_SCIENCE
NONE
Study Groups
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Adolescent Teenagers
Participants aged 13-15 (approximately Tanner pubertal stage 2-4) at study entry.
Montreal Imaging Stress Task
Psychosocial stress procedure consisting of completing sections of mental arithmetic that are 5.5 minutes in length, during which the individual receives neutral and negative evaluative feedback about their performance relative to their peers.
Trier Social Stress Test for Children
Psychosocial stress procedure in which the individual tells a story for 5 minutes in front of two neutral judges and performs mental arithmetic in front of the judges for 5 minutes.
Interventions
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Montreal Imaging Stress Task
Psychosocial stress procedure consisting of completing sections of mental arithmetic that are 5.5 minutes in length, during which the individual receives neutral and negative evaluative feedback about their performance relative to their peers.
Trier Social Stress Test for Children
Psychosocial stress procedure in which the individual tells a story for 5 minutes in front of two neutral judges and performs mental arithmetic in front of the judges for 5 minutes.
Eligibility Criteria
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Inclusion Criteria
* Ability to understand and sign an assent form
* Meets study hearing and vision requirements
Exclusion Criteria
* Current use of medications that would interfere with cardiovascular or endocrine assessments
* Metal in the body or other MRI exclusion
* Central nervous system disorder or brain injury that could confound brain imaging evaluations
* Presence of a medical condition that would interfere with cardiovascular or endocrine assessments
* Impaired intellectual functioning
* Diagnosed with a neurodevelopmental disability
13 Years
15 Years
ALL
Yes
Sponsors
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National Institute of Mental Health (NIMH)
NIH
University of North Carolina, Chapel Hill
OTHER
Responsible Party
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Principal Investigators
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Aysenil Belger, PhD
Role: PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill
Danielle Roubinov, PhD
Role: PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill
Locations
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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24-1236
Identifier Type: -
Identifier Source: org_study_id
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