Pathogenesis and Inflammatory Phenotype of Allergic Bronchopulmonary Aspergillosis

NCT ID: NCT07040332

Last Updated: 2025-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-10

Study Completion Date

2029-01-31

Brief Summary

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This study aims to reveal the immune and inflammatory regulatory molecular mechanisms related to the progression of allergic bronchopulmonary aspergillosis (ABPA), and to build a precision typing based on inflammation and identify the biomarkers of typing, and to explore the clinical outcomes of different inflammatory phenotypes.

Detailed Description

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Conditions

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Allergic Bronchopulmonary Aspergillosis (ABPA)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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allergic bronchopulmonary aspergillosis

Intervention Type OTHER

No intervention

fungal-sensitized asthma

Intervention Type OTHER

No intervention

control group

Intervention Type OTHER

No intervention

Interventions

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No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Meets the diagnostic criteria for allergic bronchopulmonary aspergillosis.
* Meets the diagnostic criteria for fungal-sensitized asthma.

Exclusion Criteria

* Human immunodeficiency virus infection.
* Malignant tumor.
* Blood system disease.
* autoimmune system disease.
* History of pulmonary tuberculosis.
* Patients with a history of smoking or still smoking.
* Invasive pulmonary fungal disease.
* Contraindications electronic bronchoscopy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shanghai Pulmonary Hospital, Tongji University School of Medicine

UNKNOWN

Sponsor Role collaborator

Fudan University

OTHER

Sponsor Role collaborator

Guizhou Provincial People's Hospital

OTHER

Sponsor Role collaborator

The First Hospital of Jilin University

OTHER

Sponsor Role collaborator

Qilu Hospital of Shandong University

OTHER

Sponsor Role collaborator

Qianfoshan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Qian Qi

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China

Jinan, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Qian Qi, Prof.

Role: CONTACT

+86 13706380314

Facility Contacts

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Qian Qi, Dr.

Role: primary

+86 13706380314

Other Identifiers

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QFS-2025-074

Identifier Type: -

Identifier Source: org_study_id

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