Patient-centered Personalized Cardiac Rehabilitation in Post Acute Coronary Syndrome (BREAK-trial)

NCT ID: NCT07038265

Last Updated: 2025-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

202 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-26

Study Completion Date

2027-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary objective of this study is to compare an integrated, multidisciplinar patient-centered CRP (Cardiac Rehabilitation Program) (intervention group) especially focused on covering the needs for the female and fragile population to the usual care conventional CRP (control group)

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The Break-CR study is designed as an unicentric, open, randomized controlled trial, blind end-point evaluation and adjudication, to compare the feasibility, efficacy, and safety of a patient-centered CR-program versus usual care in patients after an acute coronary syndrome (ACS). The project aims to identify these barriers and design a CR-intervention to overcome said barriers and evaluate its usefulness in clinical practice.

The first part of this study consists of a qualitative study to specifically determine barriers, difficulties and facilitators that condition the participation of women in the CRPs, the second part of the study is undertaken to address the underrepresentation of women in CRPs and provide a solution to the recognized need to redesign CR programs to respond to the unique physiological and psychosocial needs of women. The aim is to design a groundbreaking intervention model that will respond to this need because it will incorporate all the factors on which a CR programme should be based, from a woman's perspective, from the beginning to the end, while also adressing the needs of the fragile portion ACS survivors.

It is hypothesized that the Break-CR program would be able to demonstrate greater improvements in incorporation and adherence of women and fragile patients to CR-programs, enhanced functional benefits, as well as improve patient-satisfaction and quality of life. Finally, the fundamental purpose is to enhance poor health outcomes of women and fragile patients with coronary diseases and to provide a solution that will contribute to bridge the health gap that exists in the field of cardiovascular diseases in health systems.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Coronary Syndromes (ACS) Cardiac Rehabilitation Frailty Women Women's Health

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Patients will be recruited during 14 months, and will be followed for a fixed period of 6 months. The study protocol will be approved by the institutional review boards of the center (Bellvitge Biomedical Research Institute, IDIBELL).

The trial will be designed and implemented by the BREAK Steering Committee. Oversight of the study will be conducted by the Chair and the two Co-Chairs in liason with the BREAK Executive Committee. Safety will be reported by local investigators in accordance with the current legislation that regulates pharmacovigilance in Spain.

End-point evaluation of the primary outcome will be performed by an independent end-point committee blinded to the group allocation of patients.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Standard of care

Usual cardiac rehabilitation program

Group Type ACTIVE_COMPARATOR

Usual Care

Intervention Type OTHER

Usual cardiac rehabilitation program

Personalized intervention program

BREAK intervention group with more alternatives of aerobic and strength exercises and also offering remote options for fragile patients

Group Type EXPERIMENTAL

Personalised treatment

Intervention Type BEHAVIORAL

Patients going through a personalized intervention program

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Personalised treatment

Patients going through a personalized intervention program

Intervention Type BEHAVIORAL

Usual Care

Usual cardiac rehabilitation program

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patient aged ≥ 18 years
2. Patients discharged within the last 30 days after an admission for ACS or in the discharge planning process for an admission for ACS.
3. The patient is able to fully communicate with the research team and comply with all study procedures.
4. The patient voluntarily signs and dates the informed consent form approved by the ethics committee

Exclusion Criteria

1. Age \<18 years
2. Participation in another clinical trial
3. Moderate or severe cognitive impairment in the absence of a competent caregiver
4. Absence of social support
5. Institutionalized patient
6. Life expectancy \<1 year
7. Candidates for end-of-life care
8. Severe psychiatric illness
9. Planned cardiac surgery including transplant or circulatory support implant
10. Death before hospital discharge in patients included in the hospital discharge planning phase
11. Carrier of heart transplant.
12. Patient unable or refusing to give written informed consent to participate
13. Patients who, in the opinion of the investigator, are unsuitable candidates for the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hospital Universitari de Bellvitge

OTHER

Sponsor Role collaborator

Fundació La Marató de TV3

OTHER

Sponsor Role collaborator

Institut d'Investigació Biomèdica de Bellvitge

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Cristina Enjuanes Grau

Coordinator of Community Heart Failure Unit, Cardiology Department. MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Cristina Enjuanes, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Institut d'Investigació Biomèdica de Bellvitge

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Spain

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Cristina Enjuanes Grau, MD, PhD

Role: CONTACT

+34 93 260 7078

Pablo Morales, MD

Role: CONTACT

+34 93 260 7078

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Pablo Morales, MD

Role: primary

686385245

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IDIBELL- 202309 10

Identifier Type: -

Identifier Source: org_study_id

202309 10

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.