Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-01

Study Completion Date

2024-06-01

Brief Summary

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This study looks at whether using macrolide antibiotics is helpful and safe in treating acute chest syndrome, a serious complication in people with sickle cell disease. It reviews past cases from three hospitals where patients were treated in intensive care. The goal is to understand if macrolides make a difference, what germs are involved, how useful lab tests are, and how well patients tolerate these antibiotics.

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Detailed Description

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Conditions

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Sickle Cell Disease Acute Chest Syndrome Glucose-6-Phosphate Dehydrogenase Deficiency Anti-Bacterial Agents Macrolides

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adult patient (≥18 years old).
* Diagnosis of acute chest syndrome (ACS).
* Hospitalized in an intensive care unit (ICU).
* Microbiological sampling performed (e.g., multiplex PCR, sputum culture \[ECBC\], and/or Legionella urinary antigen test).
* Received empiric antibiotic therapy including a macrolide.

Exclusion Criteria

* Minor patient (\<18 years old).
* Acute chest syndrome not requiring ICU admission.
* Acute chest syndrome without any attempt at microbiological documentation.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No