Dense Red Blood Cells in Sickle Cell Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

82 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-12-31

Study Completion Date

2019-07-07

Brief Summary

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Quantitative and prognostic evaluation of dense red blood cells in sickle cell children: preliminary single center study from the Creteil pediatric cohort.

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Detailed Description

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An association between red blood cell density and hemolytic parameters, and clinical manifestations has been demonstrated in adults with sickle cell anemia.

This factor has not been studied in children. The identification of predictive biomarkers of disease severity, especially of specific pediatric complications (cerebral vasculopathy, splenic sequestration, Dactylitis) would be useful for optimal care of the children and early intensification Red blood cell density might be one of these prognostic factors.

Conditions

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Sickle Cell Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Common arm

Children with sickle cell anemia will be included. Blood samples of all the included patients will be collected during a day-hospitalization for a planned chek-up. For all these patients the number of dense erythrocytes will be evaluated

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age: 18 months-18 years
* Patient with sickle cell disease namely SS, or S / Beta0 or S / Beta +
* Patient regularly followed in the pediatric cohort of the CHI Creteil
* Patient Hospitalized for an annual check-up
* With or without intensification by Hydroxycarbamide
* patient who haven't been transfused within 3 months
* Whose parents have given their informed consent
* Patients insured to the French social scheme

Exclusion Criteria

* Sickle cell SC disease
* Having received an allogeneic bone marrow transplantation
* Under regular transfusion program
* Having received a transfusion within 3 months

Minimum Eligible Age

18 Months

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No