Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-04-01

Study Completion Date

2024-09-15

Brief Summary

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Comparing ketamine and ephedrine to decrease the incidence of post spinal hypotension after caesarean section delivery.

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Detailed Description

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To compare the effect of ketamine versus ephedrine in decreasing the incidence of hypotension in caesarean section delivery a study group including 50 participants will receive ketamine and 50 group will receive ephedrine after the consent and detailed history the two groups will receive preload of 500ml enter acetate then dormicum for sedation then spinal anesthesia will be performed initial blood pressure and heart rate will be measured then every five minutes

Conditions

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Post Spinal Hypotension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Ketamine group

0.5mg/kg ketamine

Group Type ACTIVE_COMPARATOR

Ketalar

Intervention Type DRUG

women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline.

Ephedrine group

15 mg ephedrine

Group Type ACTIVE_COMPARATOR

Ephedrine

Intervention Type DRUG

women receiving bolus of 15mg of ephedrine

Interventions

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Ketalar

women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline.

Intervention Type DRUG

Ephedrine

women receiving bolus of 15mg of ephedrine

Intervention Type DRUG

Other Intervention Names

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Ketamine

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing Caesarian Section under spinal anesthesia,
* Patients aged 18-45 years,
* At term (≥37-week gestation),

Exclusion Criteria

* Pre-eclampsia,
* Chronic hypertension, cardiovascular troubles,
* Any contraindication to regional anesthesia such as local infection or bleeding disorders,
* Any hypersensitivity to ketamine.
* Declined informed consent.
* American Society of Anaesthesiologists (ASA) physical status lll or lV

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes