Clinical Practices for Treating Severe Malaria Caused by P. Falciparum

NCT ID: NCT07027722

Last Updated: 2025-06-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 77 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-05-01
• Study Completion Date: 2024-05-31

Brief Summary

This study looks at how doctors in three hospitals in France treat patients with a serious form of malaria caused by Plasmodium falciparum. It focuses on cases where the level of malaria parasites in the blood is 4% or higher. The study will compare how often a type of medicine called ACT (artemisinin-based combination therapy) is used on its own instead of the usual first-choice treatment (intravenous artesunate), and whether ACT works just as well. It will also check how well patients recover, whether they have complications, and how long they stay in the hospital.

Conditions

Malaria, Falciparum; Plasmodium Falciparum; Antimalarials; Artemisinins; Treatment Outcome; Drug Therapy, Combination; Retrospective Studies; Hospitalization

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Adult patients aged 18 years or older.
• Diagnosis of Plasmodium falciparum malaria with a parasitemia level ≥ 4%.

Exclusion Criteria

• Patients under 18 years old

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier de Saint-Denis

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

France

Saint-Denis, France, France

Countries

France

Other Identifiers

0066_SMIT

Identifier Type: -

Identifier Source: org_study_id