Feasibility, Safety and Effectivity of an Exercise Intervention for Newly Diagnosed Multiple Myeloma Patients During Induction Therapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-14

Study Completion Date

2026-06-27

Brief Summary

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Physical exercise is an important supportive therapy for cancer patients, which improves quality of life and can effectively counteract the side effects of drug therapy. There is very little experience whether physical activity can also be performed safely by patients with malignant diseases that affect bone stability. This applies in particular to patients with multiple myeloma, a disease characterized by a monoclonal proliferation of plasma cells in the bone marrow and often accompanied by severe bony destruction. Aim of this exploratory randomized controlled trial is to evaluate feasibility, safety and effectivity of an orthopaedic-guided exercise intervention during induction therapy in newly diagnosed multiple myeloma patients.

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Detailed Description

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Conditions

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Multiple Myeloma Bone Lesions

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Intervention group

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type OTHER

Orthopedic consultation and home-based, individualized, structured resistance training during induction therapy.

Control group

Group Type OTHER

Control group

Intervention Type OTHER

Orthopedic consultation and stretching exercises/walking. No resistance training.

Interventions

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Exercise

Orthopedic consultation and home-based, individualized, structured resistance training during induction therapy.

Intervention Type OTHER

Control group

Orthopedic consultation and stretching exercises/walking. No resistance training.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* newly diagnosed multiple myeloma
* Survival prognosis \> 6 months
* ECOG status ≤ 3
* Age ≥18 years
* Patients who state that they want to carry out the training program at least 2 x/week and participate in the planned follow-up visits
* Ability to give informed consent
* Written consent to participate in the study
* Sufficient knowledge of written and spoken German

Exclusion Criteria

* physical or mental limitation that would prevent participation in the training program or the planned follow-up visits.
* Carrying out a regular, intensive training program (min. 1h, 2x/week)

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No