A Resilience-Based Approach to Improve Long-term Quality of Life in Post-treatment Lymphoma Survivorship

NCT ID: NCT07013435

Last Updated: 2025-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

254 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2030-01-31

Brief Summary

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The goal of this trial is to learn if a resilience intervention can lead to improvements in lymphoma survivors' quality of life.

Detailed Description

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The Stress Management and Relaxation Response Resiliency Program for lymphoma survivors (SMART3RP-Lymphoma) was adapted by researchers at the MGH. This group program seeks to buffer stress and promote psychological resiliency and physical well-being through a variety of mind-body approaches, such as imagery, relaxation, and yoga, cognitive behavioral strategies, and positive psychology tools.

The main questions it aims to answer are:

* Will survivors randomized to SMART3RP-Lymphoma demonstrate greater improvements in quality of life when compared to survivors randomized to a Health Education Program?
* Will improvements in resiliency lead to improvements in quality of life?

To answer these questions, researchers will compare a resilience intervention tailored to the needs of lymphoma survivors (SMART3RP-Lymphoma) to a Health Education Program to see how they affect quality of life of lymphoma survivors.

Participants will:

* Fill out 4 surveys across 12 months
* Participate in 8 weekly, virtual group sessions
* Submit hair cortisol samples

Conditions

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Lymphoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Health Education Program

Participants will participate in 8 weekly sessions.

Components include:

* education on the co-occurrence of mental and physical problems
* goal setting for health behavior change
* self-monitoring

HEP is an active control condition for mind body programs and is structurally equivalent to SMART3RP

Group Type ACTIVE_COMPARATOR

Health Education Program

Intervention Type OTHER

8 weekly sessions that include education on the co-occurrence of mental and physical problems, goal setting for health behavior change, and self-monitoring. Each session includes basic didactic information, interactive application of the information, and open discussion of didactic material.

SMART3RP-Lymphoma

Participants will participate in 8 weekly sessions.

The intervention components include:

* Eliciting the relaxation response (RR),
* CBT strategies to improve stress management
* Positive psychology strategies to achieve growth enhancement

Group Type EXPERIMENTAL

SMART3RP-Lymphoma

Intervention Type OTHER

The SMART3RP-lymphoma is a group program that, through a variety of mind-body approaches, such as imagery, relaxation, and yoga, seeks to buffer stress and promote psychological resiliency and physical well-being.

Interventions

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Health Education Program

8 weekly sessions that include education on the co-occurrence of mental and physical problems, goal setting for health behavior change, and self-monitoring. Each session includes basic didactic information, interactive application of the information, and open discussion of didactic material.

Intervention Type OTHER

SMART3RP-Lymphoma

The SMART3RP-lymphoma is a group program that, through a variety of mind-body approaches, such as imagery, relaxation, and yoga, seeks to buffer stress and promote psychological resiliency and physical well-being.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* English or Spanish speaking adults (18+ at time of enrollment)
* Within 2 years of completing active, curative treatment for lymphoma (includes surgery, chemotherapy, immunotherapy, radiation therapy, or other)

Exclusion Criteria

* Active psychiatric or cognitive comorbidity as determined by the site PI or treating clinician
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Massachusetts General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Giselle K. Perez Lougee

Clinical Psychologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Mass General Hospital

Boston, Massachusetts, United States

Site Status

Countries

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United States

Facility Contacts

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Giselle K Perez, PhD

Role: primary

Other Identifiers

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25-204

Identifier Type: -

Identifier Source: org_study_id

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