Treatment of Plane Warts With Topical and Oral Retinoids
NCT ID: NCT07012811
Last Updated: 2025-06-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
39 participants
INTERVENTIONAL
2024-02-12
2025-03-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group A
Patients apply tretinoin cream 0.05% once daily at night for 3 months
Topical tretinoin 0.05%
Topical tretinoin cream 0.05% applied once daily at night
Group B
Patients apply tretinoin cream 0.05% and receive oral isotretinoin capsule in the dose of 0.5 mg/kg/day for 3 months
Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)
Topical tretinoin cream 0.05% once daily at night + oral isotretinoin capsule in the dose of 0.5 mg/kg/day
Interventions
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Topical tretinoin 0.05%
Topical tretinoin cream 0.05% applied once daily at night
Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)
Topical tretinoin cream 0.05% once daily at night + oral isotretinoin capsule in the dose of 0.5 mg/kg/day
Eligibility Criteria
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Inclusion Criteria
* Patients who had not received any treatment for warts in the last month.
Exclusion Criteria
* Abnormal lipid profile.
* Significant hepatic or renal dysfunction.
* Depression.
12 Years
ALL
No
Sponsors
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Tishreen University
OTHER
Responsible Party
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Principal Investigators
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Zeina M Habib, MD
Role: PRINCIPAL_INVESTIGATOR
Tishreen University Hospital
Locations
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Tishreen University- Faculty of Medicine
Latakia, Latakia Governorate, Syria
Countries
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References
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Singh R, Pandey SS: Efficacy of topical 5% 5-fluorouracil and 0.05% tretinoin and electrosurgery in the treatment of plane warts: a randomized controlled comparative trial. Nepal J Dermatol Venereol & Leprol. 2021, 19(1):55-9
Randhawa NK, Kumar S, Agarwal US, Agarwal P, Bansal A, Meena S: To evaluate efficacy and safety of low dose oral isotretinoin (20 mg/day) alone versus combination of low dose oral isotretinoin (20 mg/day) plus topical tretinoin (0.1%) in gel formulation in the treatment of verruca plana. J Clin Exp Dermatol Res. 2023, 14:635.
Nooruldeen AD, Saeed MY: Efficacy and safety of oral isotretinoin in treatment of plane warts. Bali Med J. 2021, 10(3): 1076-7080
Dong ZY, He MJ, Hu Y, Wang F, Ran DL, Fu DS, He Q, Yang RP, Zhang JA. Unveiling the Mechanism of Retinoic Acid Therapy for Cutaneous Warts: Insights from Multi-Omics Integration. Clin Cosmet Investig Dermatol. 2024 Dec 18;17:2923-2932. doi: 10.2147/CCID.S504391. eCollection 2024.
Kaur GJ, Brar BK, Kumar S, Brar SK, Singh B. Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial. Int J Dermatol. 2017 Dec;56(12):1352-1358. doi: 10.1111/ijd.13727. Epub 2017 Sep 13.
Sterling JC, Gibbs S, Haque Hussain SS, Mohd Mustapa MF, Handfield-Jones SE. British Association of Dermatologists' guidelines for the management of cutaneous warts 2014. Br J Dermatol. 2014 Oct;171(4):696-712. doi: 10.1111/bjd.13310. Epub 2014 Oct 1. No abstract available.
Other Identifiers
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TishreenU - Plane Warts
Identifier Type: -
Identifier Source: org_study_id
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