Impact of Supraphysiological Estradiol on ECG in IVF Patients
NCT ID: NCT07007416
Last Updated: 2025-06-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
62 participants
OBSERVATIONAL
2024-12-15
2025-01-31
Brief Summary
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ECG recordings were performed twice: once before gonadotropin stimulation and again on the day of hCG administration, when peak E2 levels were expected. Routine blood tests and hormone levels were also evaluated. Patients with obesity, cardiovascular disease, chronic illness, or medication use were excluded.
After treatment, significant increases were observed in PR interval, J-Tpeak, QTc, and Tp-e values. E2 changes showed a moderate negative correlation with QTc and a low positive correlation with J-Tpeak.
The results suggest that elevated E2 levels during IVF may affect cardiac electrophysiology, highlighting the need for careful monitoring in women with cardiac risk factors.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Undergoing IVF treatment at Konya City Hospital between December 2024 and January 2025
No cardiac pathology based on cardiology consultation
Eligible for controlled ovarian stimulation using a short antagonist protocol
Provided informed consent
Exclusion Criteria
Baseline estradiol level \> 50 ng/L on day 2 of menstrual cycle
Presence of any known chronic diseases (e.g., diabetes mellitus, hypertension, rheumatologic disorders, thyroid disorders)
Use of any medications other than those used for IVF
Current smoker or alcohol user
Family history of cardiac disease or sudden cardiac death
Personal history of myocardial infarction, angina, heart failure, or any structural heart disease
History of cardiac surgery or coronary intervention
18 Years
40 Years
FEMALE
No
Sponsors
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Konya City Hospital
OTHER
Responsible Party
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Dilay Gök Korucu
Assistant Prof. of Obstetrics and Gynecology
Principal Investigators
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Dilay Gök Korucu, M.D.
Role: PRINCIPAL_INVESTIGATOR
Konya City Hospital
Locations
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Konya City Hospital
Konya, , Turkey (Türkiye)
Countries
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Other Identifiers
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2024/026
Identifier Type: -
Identifier Source: org_study_id
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