Clinical Efficacy Trial of Burdock Root Extract in Patients With Asymptomatic Hyperuricaemia

NCT ID: NCT07002762

Last Updated: 2025-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-12

Study Completion Date

2025-09-30

Brief Summary

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Multicentre, double-blind, randomized, placebo-controlled trial of the clinical efficacy of burdock root extract in patients with asymptomatic hyperuricemia, with the primary objective to assess the efficacy of the use of burdock root extract in patients with asymptomatic hyperuricaemia versus placebo

Detailed Description

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Conditions

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Hyperuricemia or Gout

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive.

Gastric soluble capsules each containing: 750 mg of burdock ( Arctium lappa L.) root extract in the form of a nutritional additive. The investigational product is packed in identical plastic containers marked as "Investigational Medicinal Product."

Group Type ACTIVE_COMPARATOR

Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive

Intervention Type DIETARY_SUPPLEMENT

Gastric soluble capsules each containing: 750 mg of burdock ( Arctium lappa L.) root extract in the form of a nutritional additive

Placebo

Intervention Type OTHER

Gastric soluble capsules each containing: Maltodextrin, silicon dioxide, calcium stearate, food colourants

Placebo

Gastric soluble capsules each containing: Maltodextrin, silicon dioxide, calcium stearate, food colourants. The placebo is packed in identical plastic containers marked as "Placebo."

Group Type PLACEBO_COMPARATOR

Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive

Intervention Type DIETARY_SUPPLEMENT

Gastric soluble capsules each containing: 750 mg of burdock ( Arctium lappa L.) root extract in the form of a nutritional additive

Placebo

Intervention Type OTHER

Gastric soluble capsules each containing: Maltodextrin, silicon dioxide, calcium stearate, food colourants

Interventions

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Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive

Gastric soluble capsules each containing: 750 mg of burdock ( Arctium lappa L.) root extract in the form of a nutritional additive

Intervention Type DIETARY_SUPPLEMENT

Placebo

Gastric soluble capsules each containing: Maltodextrin, silicon dioxide, calcium stearate, food colourants

Intervention Type OTHER

Other Intervention Names

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LOPUNID URICA-EURIKA

Eligibility Criteria

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Inclusion Criteria

* Hyperuricaemia confirmed by a laboratory, uric acid level from 360 to 540 μmol/L in women and from 420 to 540 μmol/L in men;

* Age from 35 to 65 years at the baseline;
* Patients examined by an experienced specialist not revealing any clinical evidences of gout or other somatic consequences of hyperuricaemia;
* Not taking any other nutritional additives;
* Women of reproductive age having negative pregnancy test at the baseline and at the end of the trial;
* Not taking any diuretics, or their administration based on a regimen usual for a patient, without changes;
* Not taking part in any other clinical trials;
* Consent and voluntarily signed informed consent form for participation in the clinical trial.

Exclusion Criteria

* Age \<35 or \>65 years;
* Fever (above 36.8 оС);
* Pregnancy and lactation;
* Patients with any somatic evidences of hyperuricaemia including gout taking antigout drugs during or within 6 months before the trial;
* Patients with mental disorders / taking antipsychotics or antidepressants;
* Patients not giving (informed) consent to participate in the trial;
* Patients causing doubts of the study doctor as to their motivation to comply with the trial;
* Presence of any concomitant decompensated diseases or acute conditions able to influence results of the trial;
* Alcohol abuse and drug addiction;
* Changes in taking diuretics within a month before and during the trial;
* Participation in any other clinical trial;
* Taking any nutritional additives.
Minimum Eligible Age

35 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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OMNIFARMA LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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State Institution "National Research Centre "Academician M. D. Strazhesko Institute of Cardiology

Kyiv, , Ukraine

Site Status RECRUITING

Countries

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Ukraine

Central Contacts

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Oleg V Kurchenko, MD

Role: CONTACT

+380503319653

Facility Contacts

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Valentin Shichkin

Role: primary

0633639281

Other Identifiers

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Аrctilappa-100-25

Identifier Type: -

Identifier Source: org_study_id

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