Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-01

Study Completion Date

2026-07-01

Brief Summary

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This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.

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Detailed Description

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Conditions

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Intestinal Ischemia Critical Illness Enteral Nutrition Feeding Hemodynamics Ultrasonography, Doppler

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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enteral nutrition

We'll use an enteral nutrition intervention with intact protein formulations. Initiate nasogastric tube feeding at 20ml/h and continue for 24 hours. Adjust feeding strategies based on patients' SMA blood flow reactivity.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults aged ≥18 years and ≤80 years.
* Admitted to the study with a expected stay of more than 72 hours.
* Require initiation of enteral nutrition support.

Exclusion Criteria

* Pre-existing severe gastrointestinal diseases.
* Patients with gastrointestinal bleeding.
* Patients with bowel obstruction.
* Pregnant or lactating women.
* Patients with contraindications to bedside Doppler ultrasound.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No