A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
NCT ID: NCT06991257
Last Updated: 2026-01-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE2
620 participants
INTERVENTIONAL
2025-06-19
2027-12-14
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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ARM 1
Placebo Participants will receive Placebo for up to 36 weeks
Placebo
ARM 1
ARM 2
Low dose PF-07328948 Participants will receive PF-07328948 for up to 36 weeks
Low Dose PF-07328948
ARM 2
ARM 3
Medium dose PF-07328948 Participants will receive PF-07328948 for up to 36 weeks
Medium Dose PF-07328948
ARM 3
ARM 4
High dose PF-07328948 Participants will receive PF-07328948 for up to 36 weeks
High Dose PF-07328948
ARM 4
Interventions
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Placebo
ARM 1
Low Dose PF-07328948
ARM 2
Medium Dose PF-07328948
ARM 3
High Dose PF-07328948
ARM 4
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* clinically confirmed to have a diagnosis of heart failure for at least 3 months
* New York Heart Association Class II-IV symptoms
* left ventricular ejection fraction greater than 40%
* Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
* Six-minute walking distance greater than 75 meters
Exclusion Criteria
* Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
* History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
* Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
18 Years
79 Years
ALL
No
Sponsors
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Pfizer
INDUSTRY
Responsible Party
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Principal Investigators
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Pfizer CT.gov Call Center
Role: STUDY_DIRECTOR
Pfizer
Locations
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National Heart Institute
Beverly Hills, California, United States
Orange County Research Center
Lake Forest, California, United States
Comprehensive Cardiovascular Care
Santa Maria, California, United States
FOMAT Medical Research
Santa Maria, California, United States
FWD Clinical Research
Boca Raton, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Infinite Clinical Research
Miami, Florida, United States
Flourish Research Acquisition, LLC dba Flourish Research - North Miami
Miami, Florida, United States
Amavita Research Services
North Miami Beach, Florida, United States
Clinical Site Partners, LLC dba Flourish Research
Winter Park, Florida, United States
Chicago Medical Research
Hazel Crest, Illinois, United States
NexGen Research
Fort Wayne, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Velocity Clinical Research, Lincoln, Pioneer Heart Institute
Lincoln, Nebraska, United States
NexGen Research
Lima, Ohio, United States
Headlands Horizons, LLC dba Headlands Research-Brownsville
Brownsville, Texas, United States
Valley Regional Medical Center
Brownsville, Texas, United States
North Dallas Research Associates
McKinney, Texas, United States
Northwest Houston Heart Center
Tomball, Texas, United States
Diagnostic Consultative Center - 1 Lom EOOD
Lom, Montana, Bulgaria
Diagnostic Consultative Center "Ascendent"
Sofia, Sofia (stolitsa), Bulgaria
Diagnostic Consultative Center Aleksandrovska
Sofia, Sofia (stolitsa), Bulgaria
"Multiprofile Hospital for Active Treatment Puls" AD
Blagoevgrad, , Bulgaria
Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD
Gabrovo, , Bulgaria
Medical Center Hera - Kyustendil EOOD
Kyustendil, , Bulgaria
MHAT - Heart and Brain
Pleven, , Bulgaria
University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
Plovdiv, , Bulgaria
MHAT Hadzhi Dimitar
Sliven, , Bulgaria
Richmond Clinical Trials
Richmond, British Columbia, Canada
QEII Health Sciences Centre - Victoria General Site
Halifax, Nova Scotia, Canada
Health Sciences North Research Institute
Greater Sudbury, Ontario, Canada
ACV Clinic
Greater Sudbury, Ontario, Canada
CardioQuest Research Centre
Sarnia, Ontario, Canada
Corcare
Toronto, Ontario, Canada
Community Care Building
Winchester, Ontario, Canada
Winchester District Memorial Hospital
Winchester, Ontario, Canada
CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Quebec, Canada
CHU de Quebec - Université Laval - Hotel Dieu de Quebec
Québec, Quebec, Canada
Clinique de Médecins Spécialistes
Shebrooke, Quebec, Canada
Diex Recherche Sherbrooke Est
Sherbrooke, Quebec, Canada
Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur.
Terrebonne, Quebec, Canada
Diex Recherche Trois-Rivieres
Trois-Rivières, Quebec, Canada
Sdružené Zdravotnické Zařízení Krnov
Krnov, Moravskoslezský kraj, Czechia
Kardiologicka ambulance Brno s.r.o.
Brno - Kralovo Pole, , Czechia
EFERTUS healthcare s.r.o.
Brno-Zidenice, , Czechia
EDUMED s.r.o.
Jaroměř, , Czechia
VASOMED Clinic s.r.o.
Ostrava, , Czechia
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Saint-Herblain, Loire-atlantique, France
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer
Toulon, Provence-Alpes-Côte d'Azur Region, France
Chu Grenoble Alpes
Grenoble, , France
Da Vinci Magánklinika
Pécs, Baranya, Hungary
CMed Rehabilitacios es Diagnosztikai Kozpont
Székesfehérvár, Fejér, Hungary
Ezüstfény Klinika Kft
Budapest, , Hungary
Semmelweis Egyetem
Budapest, , Hungary
Jahn Ferenc Dél-pesti Hospital
Budapest, , Hungary
New Medical Center Kft.
Sopron, , Hungary
Kasugai Municipal Hospital
Kasugai, Aichi-ken, Japan
Nagoya Tokushukai General Hospital
Kasugai, Aichi-ken, Japan
Seikeikai New Tokyo Heart Clinic
Matsudo, Chiba, Japan
Toho University Sakura Medical Center
Sakura, Chiba, Japan
Teine Keijinkai Hospital
Sapporo, Hokkaido, Japan
Koga General Hospital
Koga, Ibaraki, Japan
Sagamihara Kyodo Hospital
Sagamihara, Kanagawa, Japan
Yokohama Municipal Citizen's Hospital
Yokohama, Kanagawa, Japan
National Hospital Organization Yokohama Medical Center
Yokohama, Kanagawa, Japan
National Hospital Organization Mie Chuo Medical Center
Tsu, Mie-ken, Japan
National Hospital Organization Sendai Medical Center
Sendai, Miyagi, Japan
Kishiwada Tokushukai Hospital
Kishiwada, Osaka, Japan
National Hospital Organization Saitama Hospital
Wako, Saitama, Japan
Tokyo Metropolitan Toshima Hospital
Itabashi-ku, Tokyo, Japan
Showa General Hospital
Kodaira-shi, Tokyo, Japan
National Hospital Organization Tokyo Medical Center
Meguro-Ku, Tokyo, Japan
NewHeart Watanabe Institute
Suginami, Tokyo, Japan
Sekino Hospital
Toshimaku, Tokyo, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni, Yamaguchi, Japan
Nagasaki Harbor Medical Center
Nagasaki, , Japan
NZOZ Centrum Medyczne KERmed
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
SP ZOZ w Puławach
Puławy, Lublin Voivodeship, Poland
NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus
Sopot, Pomeranian Voivodeship, Poland
Kardio Brynow
Katowice, Silesian Voivodeship, Poland
Research and Cardiovascular Corp.
Ponce, , Puerto Rico
Parc de Salut Mar - Hospital del Mar
Barcelona, Barcelona [barcelona], Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], Spain
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario La Paz
Madrid, Madrid, Comunidad de, Spain
Hospital Clinico de Valencia
Valencia, Valenciana, Comunitat, Spain
Hospital General Universitario de Valencia
Valencia, , Spain
Hospital Universitari i Politecnic La Fe
Valencia, , Spain
Ninewells Hospital and Medical School
Dundee, Dundee CITY, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, Norfolk, United Kingdom
St Richard's Hospital
Chichester, WEST Sussex, United Kingdom
South Eastern Health and Social Care Trust
Belfast, , United Kingdom
Wycombe General Hospital
High Wycombe, , United Kingdom
Countries
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Central Contacts
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Related Links
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To obtain contact information for a study center near you, click here.
Other Identifiers
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2024-518438-94-00
Identifier Type: REGISTRY
Identifier Source: secondary_id
C4921003
Identifier Type: -
Identifier Source: org_study_id
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